ArticleJournal of molecular histology2026
The role and mechanism of 3D-printed hydrogel-CGF/PLGA composite polymer in promoting skin burn healing.
Article in Journal of molecular histology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Advanced Hydrogel Functionalization Strategies for Burn-Related Wound Treatment.Biomaterials research · 2026Review
Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
Abstract
Skin burn healing faces challenges, including delayed wound closure, high infection risk, and scar formation, necessitating the development of novel biomaterials to enhance tissue regeneration. This study investigates the promoting effect and molecular mechanism of a 3D-printed concentrated growth factor (CGF)-loaded poly (lactic-co-glycolic acid) (PLGA) microsphere composite methacryloyl gelatin (GelMA) hydrogel (GelMA-CGF-PLGA) on skin burn healing. CGF–PLGA microspheres were prepared via a double emulsion method, and their morphology and particle size were characterized. The GelMA was synthesized and 3D‑printed into hydrogel scaffolds, followed by evaluation of their rheological properties and biocompatibility. In vitro experiments (cell viability, macrophage polarization, and angiogenesis) and a rat burn model were used to analyze the material’s anti-inflammatory, pro-angiogenic, and wound healing effects. The 3D-printed GelMA hydrogel demonstrated a uniform pore structure (approximately 500 μm in diameter) with consistent elasticity, excellent biocompatibility, and sustained release profiles for vascular endothelial growth factor and platelet-derived growth factor-BB. In vitro experiments revealed that the GelMA-CGF-PLGA composite significantly enhanced the viability of human skin fibroblasts (HSFs), suppressed M1 macrophage polarization, and promoted angiogenic activity. Furthermore, in a rat burn model, treatment with GelMA-CGF-PLGA resulted in markedly accelerated wound closure compared to control groups. GelMA–CGF–PLGA significantly accelerates burn wound healing by synergistically regulating the inflammatory microenvironment, promoting angiogenesis, and facilitating collagen remodeling.
Indexed as
Identifiers
41843328What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.