Evidence map›Paper›PMID 41843308›Full record

ArticleIndian pediatrics2026

Celiac Disease and HLADQ2/DQ8 Genotypes in Severe Acute Malnutrition: A Hospital-Based Study.

Swetketu Singh, Ankur Singh, Vinod Kumar, Ved Prakash Singh, Akhtar Ali, Amrita Ghosh Kar, Abhishek Abhinay, Rajniti Prasad

Abstract read
PubMed Publisher
In one paragraph

Article in Indian pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Swetketu SinghDepartment of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Ankur SinghDepartment of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India. pediaankur@gmail.com.ORCID http://orcid.org/0000-0002-9419-8972
Vinod KumarDepartment of Gastroenterology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Ved Prakash SinghCentre for Genetic Disorders, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Akhtar AliCentre for Genetic Disorders, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Amrita Ghosh KarDepartment of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Abhishek AbhinayDepartment of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Rajniti PrasadDepartment of Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo determine the proportion of celiac disease (CD) among children with severe acute malnutrition (SAM) and to evaluate the distribution and association of HLA-DQ2/DQ8 genotypes in affected children.

methodsChildren aged 6-59 months diagnosed with SAM were assessed for inclusion. Those with secondary causes of SAM like underlying chronic illnesses like congenital heart disease, renal disease, or immunodeficiency were excluded. All participants were tested for tissue transglutaminase (tTG) immunoglobulin A serology, endoscopic biopsy of duodenum and HLA DQ2/DQ8 genotyping. tTG IgA serology positive and histopathology compatible (Modified Marsh grade ≥ II) cases were grouped as group A (SAM with CD). Rest of the cases were grouped as group B (SAM without CD).

resultsOut of 140 children with SAM, 20 with secondary causes of malnutrition were excluded. 40 out of 140 participants (28.57%) were tTG IgA positive with duodenal biopsy confirmatory of CD (group A). HLA-DQ2/DQ8 positivity was observed in 95% in group A and 57% of group B (P < 0.001). The most frequent genotype was HLA-DQ2.5 (67.5% in group A, 35% in group B; OR = 3.86, 95% CI 1.72-8.63).

conclusionA substantial proportion of children with SAM have undiagnosed CD with HLA-DQ2.5 genotype being the most common genotype.

Indexed as

Celiac DiseaseHLA-DQ AntigensChild, PreschoolDuodenumFemaleGenotypeHumansImmunoglobulin AInfantMaleTransglutaminasesHLA-DQ2 antigenHLA-DQ8 antigenHLA-DQ AntigensImmunoglobulin ATransglutaminasesAnti-tTGGenetic predispositionGluten enteropathyGrowth failureMarsh grading

Identifiers

PMID41843308

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.