ArticleAnnals of biomedical engineering2026
Mechanobiological Response of Osteocyte TRPV4 Base on the Piezoelectricity of Bone Matrix.
Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Maintenance of bone health by osteoblasts in the absence of osteocytes: comparative analysis of gene expression in medaka and zebrafish vertebrae.Bone reports · 2026Article
- Immunometabolic reprogramming in osteoporosis-osteoarthritis comorbidity: from inflammaging to osteochondral unit degeneration.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
purposeOsteocytes are force-sensitive cells possessing a complex lacunar-canalicular system (LCS), embedded within a piezoelectric bone matrix. TRPV4, as a key mechanosensor, plays a crucial role in osteocyte mechanotransduction and related bone disorders. However, the mechanisms underlying its force sensing, mechanical signaling pathways, and biomechanical response remain poorly understood.
methodsTo address this issue, this study established a finite element model incorporating multiple mechanosensors-including bone matrix, LCS, osteocytes, and TRPV4-based on the piezoelectric effect. By integrating the multiphysics coupling of solid mechanics, fluid mechanics, and electric fields to simulate the complex effects on osteocytes, the model calculated stress, strain, and fluid shear stress (FSS) on TRPV4.
resultsResult indicate that piezoelectricity significantly increases stress and strain in TRPV4, particularly FSS. Biomechanical parameters of TRPV4 exhibit significant variations across different locations, with the highest stress levels observed at the cell processes (Maximum increase of approximately 300%). Stress distribution patterns also differ across distinct regions, while stress concentration in TRPV4 primarily occurs in its transmembrane domain and ion channel regions. This study reveals that upon coupling with primary cilia and RhoA, the mechanical response mechanism of TRPV4 undergoes significant alteration. TRPV4 exhibits greater sensitivity to fluid shear stress, whereas Piezo1 responds more strongly to membrane stress.
conclusionsThis study elucidates the microscopic mechanical response mechanism and gating activation mechanism of TRPV4 within complex bone cell environments. It clarifies the interaction mechanisms between TRPV4 and other cellular structures, providing a research pathway for understanding bone cell mechanical transduction mechanisms and complex interactions across multiple scales. This work offers theoretical insights into the pathogenesis and therapeutic approaches for TRPV4-related bone disorders.
Indexed as
Identifiers
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Registered trials
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