Evidence map›Paper›PMID 41843283›Full record

ArticleJournal of physiology and biochemistry2026

Aerobic exercise improve physical endurance and muscle function by ameliorating oxidative stress and modulating mitochondrial dynamics in aged skeletal muscle.

Fengting Zheng, Jiawei Zhou, Yangfan Cao, LuYi Lin, Wenxin Wang, Liang Zhang, Wei Li, Ting Li, Lifeng Wang

Abstract read
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In one paragraph

Article in Journal of physiology and biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fengting Zheng *College of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua, 321004, China.
Jiawei Zhou *College of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua, 321004, China.
Yangfan CaoCollege of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua, 321004, China.
LuYi LinCollege of Foreign Languages, Zhejiang Normal University, Jinhua, 321004, China.
Wenxin WangCollege of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua, 321004, China.
Liang ZhangCollege of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua, 321004, China.
Wei LiCollege of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua, 321004, China.
Ting LiCollege of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua, 321004, China. tingli@zjnu.edu.cn.
Lifeng WangCollege of Physical Education and Health Sciences, Zhejiang Normal University, Jinhua, 321004, China. wanglifeng@zjnu.edu.cn.

Funding

Zhejiang Provincial Natural Science Foundation of China LY19C110002
6 · The paper itself

Abstract

Mitochondrial dysfunction is associated with the age-related decline in skeletal muscle mass and strength. Aerobic exercise upregulate Sestrins protein expression in skeletal muscle, which plays a key role in maintaining mitochondrial homeostasis. This study aimed to elucidate the role of aerobic exercise in regulating mitochondrial dynamics and oxidative stress in aging skeletal muscle. We randomly assigned male C57BL/6J mice into four groups: Young Control Group (YC), Young Aerobic Exercise Group (YA), Old Control Group (OC) and Old Aerobic Exercise Group (OA). We confirmed that aerobic exercise significantly enhanced grip strength and running capacity in aged mice compared to the OC group. The OC group exhibited significantly elevated MDA levels in skeletal muscle compared to the YC group, whereas aerobic exercise reduced MDA levels while increasing SOD and CAT activities in exercise group. Compared to the YC group, aging significantly reduced Sestrin1 protein expression, while Sestrin2 and Sestrin3 levels remained unaffected. Notably, aerobic exercise intervention significantly elevated Sestrin1 expression in OA group, compared to OC group, while no observable effects on Sestrin2/3 expression. Additionally Phospho-AMPK (Thr172), and PGC-1α were significantly increased in both the YA and OA groups. Aging also caused a marked decline in SDH activity and an increase in PGAM5 and OPA1 protein levels in the OC group. In addition, aerobic exercise improved SDH activity and augmented MFN2, OPA1 and PINK1 expression in YA and OA groups. In conclusion, aging induces oxidative stress accumulation and mitochondrial dysfunction in skeletal muscle, whereas 8-week of aerobic exercise mitigates these effects by upregulating Sestrin1 and its downstream targets, thus enhancing mitochondrial dynamics and function in aged mice.

Indexed as

AgingMitochondrial DynamicsMitochondria, MuscleMuscle, SkeletalOxidative StressPhysical Conditioning, AnimalPhysical EnduranceAMP-Activated Protein KinasesAnimalsMaleMiceMice, Inbred C57BLPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaSestrinsAMP-Activated Protein KinasesPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mouseSestrinsAerobic exerciseAgingMitochondriaOxidative stressSkeletal muscle

Identifiers

PMID41843283

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.