Evidence map›Paper›PMID 41843227›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026

The impact of integrative medicine on quality of life in patients with diabetes mellitus and cancer.

Sameer Kassem, Orit Gressel, Noah Samuels, Nili Stein, Benjamin Glaser, Eran Ben-Arye

Registry-linked trialAbstract readPragmatic Clinical TrialControlled Clinical Trial
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01860365 (Measuring Concerns and Needs of Cancer Patients Referred to Complementary Medicine Treatment Integrated Within the Oncology Service), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01860365 naunknown statusnot on this map

Measuring Concerns and Needs of Cancer Patients Referred to Complementary Medicine Treatment Integrated Within the Oncology Service

TypeinterventionalSponsorCarmel Medical CenterRan2009 to 2025Enrolled2,500ConditionsQuality of LifeArmsComplementary medicine consultation and treatment, Patients receiving conventional supportive care
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sameer KassemRappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. sameerk@technion.ac.il.ORCID http://orcid.org/0000-0003-3588-0338
Orit GresselRappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Noah SamuelsCenter for Integrative Complementary Medicine, Faculty of Medicine, Shaare Zedek Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel.
Nili SteinDepartment of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel.
Benjamin GlaserDepartment of Endocrinology and Metabolism, Faculty of Medicine, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel.
Eran Ben-AryeRappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIntegrative complementary medicine (ICM) combines complementary therapies with conventional supportive and palliative care to address quality of life (QoL). Diabetes mellitus (DM) is prevalent among patients with cancer and has been associated with worse health-related QoL. We examined the impact of an ICM program on QoL-related concerns among patients being treated for cancer, with vs. without DM.

methodsThis prospective, controlled and pragmatic study examined a 6-week ICM program, comparing DM to non-DM patients using the ESAS (Edmonton Symptom Assessment Scale) and EORTC QLQ-C30 (European Organization for Research and Treatment of Cancer Quality of Life Questionnaire) tools. The threshold for statistical significance was established at a P-value of less than 0.05.

resultsOf 671 patients, 135 (20%) had DM, with similar baseline QoL-related concerns (pain, fatigue, gastrointestinal and emotional concerns) in both groups. DM patients (vs. non-DM) responded significantly less on drowsiness on ESAS (P = 0.047); and emotional functioning on EORTC (P = 0.017). Compared to baseline, the non-DM group showed significant improvement in fatigue and sleep quality (on ESAS and EORTC; P < 0.001), while the DM group did not show any improvement for these concerns.

conclusionPatients with cancer and DM showed a less significant response to ICM treatments when compared to non-DM patients, emphasizing the need for identifying this sub-population of patients while creating specialized ICM programs tailored to their needs. Future research should focus on exploring the impact of ICM programs on patients with both DM and cancer. Trial registration ClinicalTrials.gov NCT01860365, 2013-05-21.

Indexed as

Complementary TherapiesDiabetes MellitusIntegrative MedicineNeoplasmsQuality of LifeAdultAgedFemaleHumansMaleMiddle AgedPalliative CareProspective StudiesSurveys and QuestionnairesDiabetesIntegrative complementary medicineIntegrative medicineQuality of lifeSupportive care

Identifiers

PMID41843227
PMCPMC12995945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.