ReviewCurrent oncology reports2026
Revisiting the Immune Frontier in Soft Tissue Sarcomas.
Review in Current oncology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- ESR Bridges: new developments in imaging and treatment of soft tissue sarcoma-a multidisciplinary view.European radiology · 2026Article
- Pleomorphism in Soft Tissue Sarcomas: Molecular Characteristics and Clinical Features.Medical sciences (Basel, Switzerland) · 2026Review
- High-Grade Undifferentiated Pleomorphic Sarcoma of the Distal Tibia Presenting as a Radiographically Benign-Appearing Lesion: A Case Report and Review of the Literature.Diagnostics (Basel, Switzerland) · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewSoft tissue sarcomas (STS) comprise a heterogeneous group of mesenchymal malignancies with limited treatment options and poor outcomes in the advanced setting. Although immune checkpoint inhibitors have transformed the management of many solid tumors, their efficacy in STS has been modest and strongly histology dependent. This review aims to synthesize recent advances in immuno-oncology as applied to STS and to highlight emerging strategies that may overcome resistance and improve patient outcomes. RECENT
findingsThus far, clinically meaningful activity of immune checkpoint inhibitors has been identified select STS subtypes, including undifferentiated pleomorphic sarcoma, angiosarcoma, and alveolar soft part sarcoma. Combination approaches incorporating immune checkpoint inhibitors with chemotherapy, radiation, tyrosine kinase inhibitors, or novel immune modulators have shown enhanced antitumor activity in early-phase and randomized trials. In parallel, engineered T-cell therapies targeting cancer-testis antigens have emerged as a standard-of-care option in synovial sarcoma and are being expanded to other histologies. Finally, advances in tumor microenvironment characterization, including the role of tertiary lymphoid structures and myeloid modulation, are refining patient selection and informing rational trial design. Immunotherapy continues to reshape the therapeutic landscape of soft tissue sarcoma. While immune checkpoint blockade alone benefits only a subset of patients, rational combination strategies and cellular therapies offer promising avenues to broaden clinical efficacy. Continued integration of biomarker-driven approaches, translational correlative studies, and histology-specific trial designs will be essential to fully realize the potential of immunotherapy in STS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.