Evidence map›Paper›PMID 41843130›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Severe renovascular hypertension in an infant with a SMAD3 gene variant.

Marianna Lichosik, Agata Błażejczyk, Andrzej Biełanowicz, Jan Koziej, Łukasz Obrycki, Mieczysław Litwin

Abstract readCase Reports
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In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

6 authors.

Marianna LichosikDepartment of Nephrology, Kidney Transplantation and Hypertension, The Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730, Warsaw, Poland.
Agata BłażejczykFaculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszyński University, Warsaw, Poland.
Andrzej BiełanowiczFaculty of Medicine, Collegium Medicum, Cardinal Stefan Wyszyński University, Warsaw, Poland.
Jan KoziejDepartment of Nephrology, Kidney Transplantation and Hypertension, The Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730, Warsaw, Poland.
Łukasz ObryckiDepartment of Nephrology, Kidney Transplantation and Hypertension, The Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730, Warsaw, Poland. l.obrycki@ipczd.pl.ORCID http://orcid.org/0000-0002-5134-8643
Mieczysław LitwinDepartment of Nephrology, Kidney Transplantation and Hypertension, The Children's Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730, Warsaw, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRenal artery stenosis is one of the severe secondary hypertension (HTN) causes in children and may lead to hypertension-mediated organ damage (HMOD), including left ventricle hypertrophy (LVH). CASE REPORT/TREATMENT: We describe a case of a 4-year-old boy with severe renovascular HTN and LVH during infancy. Genetic testing revealed variant of unknown significance in SMAD3, a gene linked to Loeys-Dietz syndrome. The patient was treated with intensive pharmacotherapy and percutaneous intravascular intervention.

conclusionsEarly onset of HTN and HMOD should prompt consideration of genetic evaluation to aid diagnosis and management. In this case, a heterozygous SMAD3 variant coexisted with renal artery stenosis without the development of aortic aneurysms.

Indexed as

Hypertension, RenovascularHypertrophy, Left VentricularLoeys-Dietz SyndromeRenal Artery ObstructionSmad3 ProteinAntihypertensive AgentsChild, PreschoolHumansMaleAntihypertensive AgentsSmad3 ProteinSMAD3 protein, humanHypertensionHypertension-mediated organ damageLeft ventricular hypertrophyRenal artery stenosisSMAD3 variant

Identifiers

PMID41843130

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.