Evidence map›Paper›PMID 41843109›Full record

ReviewArchives of microbiology2026

Beyond new pills: integrative strategies to overcome multidrug-resistant bacteria.

Poonam Sahu, Trilochan Satapathy

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Poonam SahuColumbia Institute of Pharmacy, Vill-Tekari, Near Vidhansabha, Raipur, Chhattisgarh, 493111, India. poonamsahu152@gmail.com.ORCID http://orcid.org/0000-0003-4398-003X
Trilochan SatapathyColumbia Institute of Pharmacy, Vill-Tekari, Near Vidhansabha, Raipur, Chhattisgarh, 493111, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relentless global spread of multidrug-resistant (MDR) bacteria has outpaced the discovery of new antimicrobials, threatening to reverse decades of medical progress. The diminishing efficacy of traditional antibiotics underscores the urgent need for transformative, integrative strategies that combine innovative therapeutics, precision diagnostics, advanced delivery platforms and global policy interventions. This review examines recent advances and emerging technologies designed to overcome MDR pathogens. We synthesize developments in next-generation antibiotics, bacteriophage and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) based therapies, antimicrobial peptides (AMPs), nanotechnology-enabled delivery systems, rapid molecular diagnostics and artificial intelligence (AI)-driven drug discovery. We also assess host-directed approaches, anti-virulence strategies and biofilm disruption techniques that complement traditional antibacterial interventions. Finally, we address the implementation science underlying stewardship, surveillance, and policy reforms required to sustain innovation and equitable access. We argue that the path forward will depend not on a single discovery but on a convergent ecosystem of biological, technological and policy innovations that together can outmaneuvre bacterial evolution.

Indexed as

Anti-Bacterial AgentsBacteriaBacterial InfectionsDrug Resistance, Multiple, BacterialAntimicrobial PeptidesBacteriophagesBiofilmsDrug DiscoveryHumansNanotechnologyAnti-Bacterial AgentsAntimicrobial Peptidesantimicrobial peptidesantimicrobial resistancebacteriophage therapyCRISPR-based antimicrobialsmultidrug-resistant bacteriarapid molecular diagnostics

Identifiers

PMID41843109

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.