Observational studySupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Symptom distress evolution over the first year after allogeneic stem cell transplantation - a prospective observational sub-study of the SMILe project.
Observational study in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04789863 (Towards Implementation of an Integrated Model of Care in Long-Term Follow-Up After Allogeneic Hematopoietic SteM Cell TransplantatIon faciLitated by eHealth Technology), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Towards Implementation of an Integrated Model of Care in Long-Term Follow-Up After Allogeneic Hematopoietic SteM Cell TransplantatIon faciLitated by eHealth Technology (The SMILe Project) - An Effectiveness-implementation Science Study
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeSymptom-related distress after allogeneic stem cell transplantation (alloSCT) significantly impairs quality of life and long-term health. However, symptom distress evolution is not substantiated and potential influences of patient-related factors remain unclear. This study's aims were to (A1) describe first-year post-alloSCT symptom distress evolution, (A2) explore that evolution in view of three patient factors: graft-versus-host-disease (GvHD), gender, age group.
methodsThis prospective longitudinal observational sub-study of the main SMILe (SteM cell transplantatIon faciLitated by eHealth) study used demographic and clinical data of patients receiving the SMILe Integrated Care Model, and their electronic patient-reported symptom distress outcomes. Patients reporting ≥ 1 time pre- and regularly post-alloSCT on 10 relevant symptoms (distress = 1-10 scale, none = 0), were included. We calculated distress point prevalences at 10 time points and plotted distress score trajectories, determining distress durations and distress persisting > 30 days uninterrupted throughout the first year post-alloSCT (A1). We used boxplot faceting visualising distress persistence by patient factors, and sought parallel-evolving GvHD and distress point prevalences (A2).
resultsFour symptoms contributed to the highest distress point prevalences (fatigue 48.2-76.9%, decreased appetite 21.7-56.9%, pain 25.4-47.7%) and high-scoring distress trajectories (≥ 3 in fatigue, decreased appetite, dyspnea) - with months of uninterrupted distress (65.7% of patients). We identified at-risk patient groups with exceptional distress persistence. Parallel-evolving point prevalences from day + 90 post-alloSCT suggested GvHD influenced symptom distress.
conclusionSymptom-related distress monitoring and management in alloSCT follow-up is important. GvHD management may require gender- and age-tailored interventions against distress persistence.
trial registrationThe main SMILe study was registered at who.int/clinical-trials-registry-platform: DRKS00020347, https://trialsearch.who.int/Trial2.aspx?TrialID=DRKS00020347 , date of registration: 03/01/2020 (Freiburg) and clinicaltrials.gov: NCT04789863, https://clinicaltrials.gov/expert-search?term=NCT04789863 , first posted: 03/10/2021 (Basel).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.