Evidence map›Paper›PMID 41842930›Full record

ArticleeLife2026

The Fd4 transcription factor translates transient spatial cues in progenitors into long-term lineage identity.

Sen-Lin Lai, Chris Q Doe

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sen-Lin LaiInstitute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, United States.ORCID https://orcid.org/0000-0002-7531-283X
Chris Q DoeInstitute of Neuroscience, Howard Hughes Medical Institute, University of Oregon, Eugene, United States.ORCID https://orcid.org/0000-0001-5980-8029

Funding

National Institute of Health Sciences HD27056
6 · The paper itself

Abstract

Neural diversity is required for the brain to generate complex behaviors. During development, neural progenitors are exposed to different combinations of transient spatial cues for their identity specification. This identity is then interpreted by their progeny to activate terminal selector genes to become lineage-specific neurons. After spatial cues fade, it remains unclear how progenitors maintain their unique identity so that their progeny express the accurate, lineage-specific terminal selector genes. Using single-cell RNA sequencing in

Indexed as

Cell LineageDrosophila melanogasterDrosophila ProteinsNeural Stem CellsTranscription FactorsAnimalsGene Expression Regulation, DevelopmentalNeuronsSingle-Cell Gene Expression AnalysisDrosophila ProteinsTranscription Factorsdevelopmental biologyD. melanogasterFd4NB7-1neuroblastneuroscience

Identifiers

PMID41842930
PMCPMC12995288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.