Evidence map›Paper›PMID 41842679›Full record

ArticleAmerican journal of speech-language pathology2026

A Comparison of Four Selected Acoustic Measures in Detecting Voice Quality Changes With Botulinum Toxin Treatment in Adductor-Type Laryngeal Dystonia.

Jenny L Pierce, Kaitlyn Dwenger, Anuja Sharma, Skyler G Jennings, Marshall Smith, Julie Barkmeier-Kraemer

Abstract readComparative Study
In one paragraph

Article in American journal of speech-language pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jenny L PierceDepartment of Otolaryngology, The University of Utah, Salt Lake City.ORCID 0000-0001-6084-3980
Kaitlyn DwengerDepartment of Otolaryngology, The University of Utah, Salt Lake City.ORCID 0000-0003-4225-8387
Anuja SharmaDepartment of Otolaryngology, The University of Utah, Salt Lake City.ORCID 0000-0002-1648-6282
Skyler G JenningsDepartment of Communication Sciences and Disorders, The University of Utah, Salt Lake City.ORCID 0000-0001-7750-8396
Marshall SmithDepartment of Otolaryngology, The University of Utah, Salt Lake City.ORCID 0000-0002-8818-9287
Julie Barkmeier-KraemerDepartment of Otolaryngology, The University of Utah, Salt Lake City.ORCID 0000-0002-5037-3070

Funding

Understanding disorder-specific neural pathophysiology in laryngeal dystonia and voice tremorP50DC019900 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Kristina Simonyan · 2021 to 2026
$11.9M
Physiologic Correlates of Vocal Tremor affecting those with Essential TremorR01DC016838 · NIDCD · UNIVERSITY OF UTAH · PI BARKMEIER-KRAEMER, JULIE M · 2019 to 2023
$3.0M
NIDCD NIH HHS P50 DC019900NIDCD NIH HHS R01 DC016838
6 · The paper itself

Abstract

purposeAdductor-type laryngeal dystonia (AdLD) is a voice disorder with substantial negative effects. The current standard treatment is botulinum toxin (BoNT) injections, with novel treatments on the horizon. The aim of this study was to determine the sensitivity of selected acoustic measures to measure voice quality change from pre-BoNT to the participants' perceived maximum benefit from BoNT.

methodTwenty-three participants with AdLD underwent acoustic recordings at pre-BoNT and a subset of 12 participants during the participants' perceived maximum benefit from BoNT. Four acoustic measures were employed: (a) cepstral peak prominence-smoothed (CPPS) estimated in Praat, (b) the cepstral spectral index of dysphonia (CSID), (c) percent creak (%creak), and (d) sharpness (a measure of vocal strain). The four measures were also compared with listener ratings and Voice Handicap Index (VHI-10) scores.

resultsThe CPPS, CSID, and %creak measures showed significant treatment-related change (

conclusionsBased on these results, CPPS, CSID, and %creak showed utility in assessing voice quality change from pre- to post-BoNT treatment in those with AdLD, with some differences across measures. Future research with novel treatments for AdLD may benefit from utilization of these measures including comparison of effect sizes with degree of improvement from BoNT outcomes.

Indexed as

Botulinum ToxinsDystoniaLaryngeal DiseasesSpeech AcousticsSpeech Production MeasurementVoice DisordersVoice QualityAdultAgedFemaleHumansLaryngeal MusclesMaleMiddle AgedTreatment OutcomeBotulinum Toxins

Identifiers

PMID41842679
PMCPMC13151812

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.