ArticleThe American journal of surgical pathology2026
Micronests in Tumor Stroma is a Prognostic Classifier in Nasopharyngeal Carcinoma.
Article in The American journal of surgical pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The assessment of micronests in tumor stroma has been introduced recently for the prognostication of human malignancies. In this multicenter study, we included a total of 110 patients treated for nasopharyngeal carcinoma (NPC) at one of the Finnish University Hospitals. All available hematoxylin and eosin (H&E)-stained slides were scanned. Assessment of micronests in tumor stroma was conducted on scanned HE-stained slides. Presence of micronests in tumor stroma had a significant prognostic value in predicting overall survival in the multivariable analysis with a hazard ratio (HR) of 1.92 (95% CI: 1.14-3.24, P=0.01). Similarly, in the multivariable analysis of disease-specific survival, micronests in tumor stroma had a significant prognostic value with an HR of 1.87 (95% CI: 1.00-3.48, P=0.04). In addition, the presence of micronests in tumor stroma showed a significant association with keratinizing and EBV-negative tumors (P<0.001). In conclusion, the evaluation of micronests in tumor stroma can be used as a prognostic classifier in NPC and they can be assessed in routine H&E-stained sections.
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