Evidence map›Paper›PMID 41841741›Full record

ArticleJournal of virology2026

Locus-specific proteomics identifies novel regulators of Epstein-Barr virus lytic reactivation.

Daniel E Greaves, Ildar Gabaev, James C Williamson, Stuart Bloor, Sergio Martinez Cuesta, Nicholas J Matheson, Lori Frappier, Jérôme Déjardin, Paul J Lehner

Abstract read
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniel E GreavesDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.ORCID 0009-0005-6417-176X
Ildar GabaevDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
James C WilliamsonDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Stuart BloorDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Sergio Martinez CuestaData Sciences and Quantitative Biology, Discovery Sciences, R&D BioPharmaceuticals, Cambridge, United Kingdom.
Nicholas J MathesonDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.
Lori FrappierDepartment of Molecular Genetics, University of Toronto, Toronto, Canada.ORCID 0000-0003-0110-5472
Jérôme DéjardinInstitute of Human Genetics, CNRS-UMR9002-Université de Montpellier, Montpellier, France.
Paul J LehnerDepartment of Medicine, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0001-9383-1054

Funding

Wellcome Trust 227418/Z/23/Z
6 · The paper itself

Abstract

The Epstein-Barr virus (EBV) is a human gamma-herpesvirus which infects over 90% of the global population and is associated with lymphoid and epithelioid cancers. After infection, EBV enters a latent state in B cells, whereby the viral genome persists as a nuclear episome maintained by expression of a small number of latency-associated viral proteins. The lytic viral proteins, required for DNA replication and virion production, are silenced by cellular epigenetic mechanisms. The immediate-early lytic gene BZLF1 is the most important target for transcriptional repression, as its expression triggers the lytic cascade. To gain insight into the factors restricting BZLF1 expression, we used the PICh method of locus-specific proteomics (

Indexed as

Epstein-Barr Virus InfectionsHerpesvirus 4, HumanProteomicsVirus ActivationB-LymphocytesCell Line, TumorEpigenesis, GeneticGene Expression Regulation, ViralHistonesHost-Pathogen InteractionsHumansMi-2 Nucleosome Remodeling and Deacetylase ComplexPromoter Regions, GeneticTrans-ActivatorsViral ProteinsVirus LatencyBZLF1 protein, Herpesvirus 4, HumanHistonesMi-2 Nucleosome Remodeling and Deacetylase ComplexTrans-ActivatorsViral Proteinsde-ubiquitinaseepigeneticsEpstein-Barr viruslocus specific proteomicsNuRD complexPolycomb complexvirus activationvirus latency

Identifiers

PMID41841741
PMCPMC13098237

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.