Evidence map›Paper›PMID 41841724›Full record

ArticleMicrobiology spectrum2026

Evaluation of serine protein kinase HPrK as an antibacterial target in gram-positive bacteria and mycoplasmas.

Hengfei Yan, Jiajia Xu, Tingting Jiang, Siyang Lu, Yuling Liu, Ying Sun, Hongyu Wu, Qiao Hu, Lu Li, Qi Huang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hengfei YanState Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.ORCID 0009-0009-4427-4664
Jiajia XuState Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Tingting JiangState Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Siyang LuState Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Yuling LiuState Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Ying SunState Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Hongyu WuState Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.
Qiao HuKey Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry of Agriculture and Rural Affairs of China), Hubei Provincial Key Laboratory of Animal Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China.
Lu LiState Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0001-5159-0045
Qi HuangState Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0002-1600-1169
Tengfei ZhangKey Laboratory of Prevention and Control Agents for Animal Bacteriosis (Ministry of Agriculture and Rural Affairs of China), Hubei Provincial Key Laboratory of Animal Pathogenic Microbiology, Institute of Animal Husbandry and Veterinary, Hubei Academy of Agricultural Sciences, Wuhan, China.ORCID 0000-0001-5060-1486
Rui ZhouState Key Laboratory of Agricultural Microbiology, Hubei Hongshan Laboratory, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China.ORCID 0000-0002-7903-9965

Funding

National Key Research and Development Program of China 2021YFD1800401
6 · The paper itself

Abstract

Antimicrobial resistance (AMR) poses a serious threat to global public health. To tackle this challenge, identifying novel effective antibacterial targets and antibiotics is crucial. The serine kinase HPrK, widely present in gram-positive bacteria and mycoplasmas, primarily regulates carbon metabolism and virulence factor expression. In a previous study, we failed to knockout the IMPORTANCE: Antimicrobial resistance (AMR) is a critical global health challenge, highlighting the need for new antibiotic targets. HPrK is a serine kinase that is important in regulation of carbon metabolism and virulence in gram-positive bacteria and mycoplasmas. In this study, we validated that HPrK was an essential gene in

Indexed as

Anti-Bacterial AgentsBacterial ProteinsGram-Positive BacteriaProtein Serine-Threonine KinasesAnimalsHumansMicrobial Sensitivity TestsProtein Kinase InhibitorsStreptococcus suisAnti-Bacterial AgentsBacterial ProteinsProtein Kinase InhibitorsProtein Serine-Threonine Kinasesantimicrobial targetessential protein kinaseHPrKinhibitor screeningStreptococcus suis

Identifiers

PMID41841724
PMCPMC13055401

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.