ArticleThe Journal of clinical endocrinology and metabolism2026
Elevated periostin level in serum of adults with osteogenesis imperfecta is associated with disease severity.
Article in The Journal of clinical endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Elevated periostin level in serum of adults with osteogenesis imperfecta is associated with disease severity.The Journal of clinical endocrinology and metabolism · 2026Article
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10 authors.
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Abstract
objectiveIn osteogenesis imperfecta (OI), phenotypic variability and the limited predictive value of genotype-phenotype correlations underscore the need for reliable predictive marker of disease severity. Periostin is a matricellular protein involved in bone formation, remodeling, and response to mechanical stress. It interacts with type I collagen and modulates osteoblast activity via Wnt/β-catenin and TGF-β signaling. Given its established role in other bone disorders, we hypothesized that circulating periostin may be a relevant biomarker in OI.
methodsWe performed a matched case-control analysis of serum periostin levels in 61 adult patients with OI and 61 age-, sex-, and BMI-matched controls. Periostin was measured by ELISA. Associations between periostin levels and clinical variables were assessed using t-tests, Pearson correlations, and multivariable linear regression models.
resultsMean periostin levels were significantly higher in OI patients than in controls (796.5 ± 209 vs 713.6 ± 167 pmol/L, P = .017). Among OI patients, higher periostin level was associated with female sex (P = .01), presence of scoliosis (P = .01), and Sillence type III (P = .05). Positive correlations were observed between periostin and markers of axial skeletal severity as height-wingspan discrepancy (r = 0.30, P = .023). In multivariable analysis, the number of severe fractures (defined as femur/pelvis/humerus/vertebral fractures) was independently associated with higher periostin level (β = 25.6, P = .041), while smoking was negatively associated (β = -269.8, P = .012).
conclusionThis study is the first to report the elevated circulating level of periostin in adults with OI and its association with disease severity.
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