Evidence map›Paper›PMID 41841642›Full record

ArticlePlatelets2026

Platelets induce VISTA expression and modulate the ovarian tumor microenvironment.

Hani Lee, Brianne Sager, Anil Sood, Vahid Afshar-Kharghan, Min Soon Cho

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Platelets, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hani LeeThe Section of Benign Hematology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Brianne SagerThe Section of Benign Hematology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Anil SoodThe Department of Gynecology Oncology & Reproductive Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Vahid Afshar-KharghanThe Section of Benign Hematology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Min Soon ChoThe Section of Benign Hematology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0002-9992-8356

Funding

U.T. M. D. Anderson Cancer Center SPORE in Ovarian CancerP50CA217685 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI SOOD, ANIL K · 2017 to 2021
$7.9M
Platelets promote growth of ovarian cancerR01CA177909 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI AFSHAR-KHARGHAN, VAHID, SOOD, ANIL K · 2013 to 2023
$4.1M
NCI NIH HHS P50 CA217685NCI NIH HHS R01 CA177909
6 · The paper itself

Abstract

Immune checkpoint regulators, such as the V-domain Ig suppressor of T cell activation (VISTA), play a critical role in shaping the tumor microenvironment (TME) and facilitating immune evasion. In ovarian cancer, VISTA exhibits more abundant and consistent expression than other immune checkpoints, including Programmed Death-Ligand 1 (PD-L1). This study examined the role of platelets in the regulation of VISTA in ovarian cancer using both in vitro and in vivo models. Our findings demonstrate that platelets upregulate VISTA expression in both myeloid and tumor cells, thereby promoting an immunosuppressive TME. Elevated VISTA levels were associated with higher platelet counts and poorer clinical outcomes. These results highlight that platelet-mediated VISTA upregulation is a potential therapeutic target for improving antitumor immune responses in ovarian cancer.

Indexed as

B7 AntigensBlood PlateletsOvarian NeoplasmsTumor MicroenvironmentAnimalsFemaleGene Expression Regulation, NeoplasticHumansMiceB7 AntigensVSIR protein, humanImmune checkpointneutrophilsovarian cancerplatelet

Identifiers

PMID41841642
PMCPMC13231984

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.