ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
The Faraday Scalpel: Electrochemical Nerve Lesioning Mechanisms Studied in Invertebrate Models.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Electrical lesioning of nervous tissue is a common surgical intervention and traditionally is carried out using high-amplitude high-frequency currents. These procedures ablate tissue via an irreversible thermocoagulation or electroporation mechanism. In this work, we explore an alternative concept of achieving lesioning using lower-amplitude direct currents (DC). DC is necessarily accompanied by faradaic reactions, which can lead to local chemical changes that affect nervous tissue. We elucidate the electrochemical mechanisms behind DC nerve lesioning using two disparate invertebrate models: the leech (Hirudo verbana) and the locust (Locusta migratoria). These represent convenient low-cost systems for investigating the effects of DC on nerve functionality with simultaneous in situ electrochemical characterization. Using thin film platinum electrodes, we find that discrete electrochemical processes and associated current magnitudes lead to different outcomes. The lowest current density regime leading to lesioning is cathodic < 100 µA/cm
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