ArticleLiver international : official journal of the International Association for the Study of the Liver2026
MASLD Is Associated With Decreased General Health Perception, Quality of Life and Work Productivity in a Low Fibrosis Population.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundData on quality of life in a low fibrosis prevalence metabolic dysfunction-associated steatotic liver disease (MASLD) cohort are scarce, as previous research has focused on advanced fibrosis and cirrhosis. This study examined the association between steatosis and general and mental health, as well as productivity in patients in primary care and a diabetes population.
methodsThree cohort studies were conducted in Belgian and Dutch primary care and a Belgian hospital. Liver stiffness (> 12 kPa) and steatosis (> 275 dB/m) were measured using vibration-controlled transient elastography and controlled attenuation parameter (CAP). Participants completed questionnaires measuring anxiety (GAD-7), depression (PHQ-9), work productivity (WPAI-SHP), and general health (SF-36), and data were analysed with Spearman correlation.
resultsOf 311 participants, 142 (45.7%) and 15 (4.7%) had steatosis and fibrosis. Individuals with steatosis had a higher BMI (30.5 kg/m
conclusionSteatosis does not appear to affect anxiety or depression, but does negatively affect general health perception and physical activity. Further investigation is needed to determine whether a potential relationship between work productivity and steatosis exists.
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