Evidence map›Paper›PMID 41841329›Full record

ArticleThe Libyan journal of medicine2026

Multi-targeted pyrazole scaffolds: synthesis, mechanistic insights, and therapeutic potential in anticancer, antioxidant, and anti-inflammatory applications.

Suhailah S Aljameel, Mohamed E Eissa, Zinab Alatawi, Hanadi A Alahmadi, Mohammad E Azab, Tarek A Yousef, Sayed K Ramadan, Hasan A Aljohi, Eida S Al-Farraj, Eman Abdullah Bahattab and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Libyan journal of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. BiogenicRSC advances · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Suhailah S AljameelDepartment of Chemistry, College of Science, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Mohamed E EissaChemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Zinab AlatawiDepartment of Family and Community Medicine, Faculty of Medicine, University of Tabuk, Tabuk, Saudi Arabia.
Hanadi A AlahmadiCollege of Health Science and Nursing, Alrayan National Colleges, Madinah, Saudi Arabia.
Mohammad E AzabChemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Tarek A YousefChemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Sayed K RamadanChemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.
Hasan A AljohiApplied Genetics Technology Institute, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Eida S Al-FarrajChemistry Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia.
Eman Abdullah BahattabThe Healthy Aging Research Institute, Health Sector, King Abdulaziz City for Science and Technology, Riyadh, Saudi Arabia.
Ahmed GhareebBotany and Microbiology Department, Faculty of Science, Suez Canal University, Ismailia, Egypt.ORCID 0000-0003-2607-5273
Eman A E El-HelwChemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyrazole derivatives are a class of heterocyclic compounds known to have broad pharmacological effects. This study aimed to synthesize and characterize a new series of pyrazole derivatives and investigate their effects on a series of

Indexed as

Anti-Inflammatory AgentsAntineoplastic AgentsAntioxidantsPyrazolesApoptosisCell ProliferationCell SurvivalComet AssayCyclooxygenase 1Cyclooxygenase 2DNA DamageDNA FragmentationHeLa CellsHumansAnti-Inflammatory AgentsAntineoplastic AgentsAntioxidantsCyclooxygenase 1Cyclooxygenase 2Pyrazolesanticancer activityanti-inflammatory activityCOX-1 and COX-2 inhibitionHeLa cellsPyrazole derivativespyrazolethione

Identifiers

PMID41841329
PMCPMC12997473

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.