Evidence map›Paper›PMID 41841259›Full record

ArticleCirculation. Heart failure2026

Simtuzumab Attenuates Loxl2-Mediated Extracellular Matrix Remodeling and Preserves Cardiac Function in

Marie Kervella, Charlotta S Behrens, Cécile Peccate, Zoheir Guesmia, Fiorella Grandi, Nathalie Mougenot, Anne Forand, Azzouz Charrabi, Guy Brochier, Ramaroson Andriantsitohaina and 4 more

Abstract read
In one paragraph

Article in Circulation. Heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Marie Kervella *Institute of Myology, Center of Research in Myology, Sorbonne University, Inserm, Paris, France (M.K., C.P., Z.G., F.G., A.F., A.M.).ORCID 0009-0009-1543-9044
Charlotta S Behrens *Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Germany (C.S.B., S.R.S., T.E.).ORCID 0000-0001-6698-0572
Cécile PeccateInstitute of Myology, Center of Research in Myology, Sorbonne University, Inserm, Paris, France (M.K., C.P., Z.G., F.G., A.F., A.M.).ORCID 0000-0002-4125-3616
Zoheir GuesmiaInstitute of Myology, Center of Research in Myology, Sorbonne University, Inserm, Paris, France (M.K., C.P., Z.G., F.G., A.F., A.M.).
Fiorella GrandiInstitute of Myology, Center of Research in Myology, Sorbonne University, Inserm, Paris, France (M.K., C.P., Z.G., F.G., A.F., A.M.).ORCID 0000-0002-1303-6710
Nathalie MougenotPhénotypage du petit animal, Inserm UMS28, Sorbonne University-UPMC Paris 06, Inserm, Paris, France (N.M.).ORCID 0000-0002-7707-234X
Anne ForandInstitute of Myology, Center of Research in Myology, Sorbonne University, Inserm, Paris, France (M.K., C.P., Z.G., F.G., A.F., A.M.).ORCID 0000-0003-4970-2372
Azzouz CharrabiPhyMedExp, University of Montpellier, Inserm, CNRS, France (M.K., A.C., R.A., A.C.M.).
Guy BrochierFunctional Unit of Neuromuscular Pathology, Neuropathology Department, Institute of Myology, CHU Pitié-Salpêtrière, Paris, France (G.B.).
Ramaroson AndriantsitohainaPhyMedExp, University of Montpellier, Inserm, CNRS, France (M.K., A.C., R.A., A.C.M.).ORCID 0000-0002-4770-3585
Sonia R SinghInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Germany (C.S.B., S.R.S., T.E.).ORCID 0000-0002-2996-7333
Thomas EschenhagenInstitute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Germany (C.S.B., S.R.S., T.E.).ORCID 0000-0003-1750-1170
Albano C Meli *PhyMedExp, University of Montpellier, Inserm, CNRS, France (M.K., A.C., R.A., A.C.M.).ORCID 0000-0002-1727-3027
Antoine Muchir *Institute of Myology, Center of Research in Myology, Sorbonne University, Inserm, Paris, France (M.K., C.P., Z.G., F.G., A.F., A.M.).ORCID 0000-0002-4780-9275

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDilated cardiomyopathy caused by

methodsHere, we employed human induced pluripotent stem cells (hiPSCs) derived from a patient carrying a

resultsWe demonstrated that

conclusionsTaken together, our findings underscore the crucial role of Loxl2 as a therapeutic target and suggest that its inhibition could be a promising strategy to preserve cardiac function in

Indexed as

Antibodies, Monoclonal, HumanizedCardiomyopathy, DilatedExtracellular MatrixLamin Type AMyocytes, CardiacVentricular Function, LeftAmino Acid OxidoreductasesAnimalsDisease Models, AnimalHumansInduced Pluripotent Stem CellsMiceMutationMyocardial ContractionPoint MutationAmino Acid OxidoreductasesAntibodies, Monoclonal, HumanizedLamin Type ALMNA protein, humanLOXL2 protein, humanchromosomesfibrosisheart failurelaminspoint mutation

Identifiers

PMID41841259
PMCPMC13095067

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.