Evidence map›Paper›PMID 41841172›Full record

ArticleMicrobiologyOpen2026

Quercetin: A Light in the Fight Against MRSA.

Maria Poliana Leite Galantini, Caroline Vieira Gonçalves, Amanda Kelle Santos Novaes, Caio Oliveira Lopes de Magalhães, Igor Pereira Ribeiro Muniz, Israel Souza Ribeiro, Paulo Henrique Bispo Lima, Maria Elisa Santos Flores, Artur Reis Carvalho, Luisa Carregosa Santos and 3 more

Abstract read
In one paragraph

Article in MicrobiologyOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Maria Poliana Leite GalantiniMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Vitória da Conquista, Bahia, Brazil.ORCID 0000-0001-9423-5334
Caroline Vieira GonçalvesMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Vitória da Conquista, Bahia, Brazil.ORCID 0000-0003-0895-1583
Amanda Kelle Santos NovaesMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Vitória da Conquista, Bahia, Brazil.ORCID 0009-0006-8393-5785
Caio Oliveira Lopes de MagalhãesMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Vitória da Conquista, Bahia, Brazil.ORCID 0009-0006-7196-161X
Igor Pereira Ribeiro MunizMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Vitória da Conquista, Bahia, Brazil.ORCID 0000-0003-1842-6432
Israel Souza RibeiroPaulo Freire Campus - Federal University of Southern Bahia, Teixeira de Freitas, Bahia, Brazil.ORCID 0000-0002-1262-1387
Paulo Henrique Bispo LimaMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Vitória da Conquista, Bahia, Brazil.ORCID 0000-0002-1672-8632
Maria Elisa Santos FloresMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Vitória da Conquista, Bahia, Brazil.ORCID 0009-0004-1843-3901
Artur Reis CarvalhoMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Vitória da Conquista, Bahia, Brazil.ORCID 0009-0002-7831-5443
Luisa Carregosa SantosMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Vitória da Conquista, Bahia, Brazil.ORCID 0009-0004-3215-8571
Daiana Silva LopesMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Vitória da Conquista, Bahia, Brazil.ORCID 0000-0002-2462-4163
Juliano Geraldo AmaralMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Vitória da Conquista, Bahia, Brazil.ORCID 0000-0003-1823-1694
Robson Amaro Augusto da SilvaMultidisciplinary Institute of Health, Anísio Teixeira Campus - Federal University of Bahia, Vitória da Conquista, Bahia, Brazil.ORCID 0000-0003-1361-1591

Funding

This study was supported by Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq, Brazil) under grant number 405884/2021-4, Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), and Fundação de Amparo à Pesquisa do Estado da Bahia (FAPESB).
6 · The paper itself

Abstract

Antimicrobial photodynamic therapy (aPDT) for treating methicillin-resistant Staphylococcus aureus (MRSA) infections has gained increasing attention in recent years. This study aimed to evaluate the potential of quercetin as a photosensitizer for aPDT. In vitro assays were conducted to assess the cytotoxicity and the antibacterial activity of quercetin photoactivated with blue LED light. In in vivo assays, and intradermal infection model was conducted in mice to evaluate the quercetin antimicrobial activity and cytokine production. The in vitro experiments showed low compound toxicity and antimicrobial activity accompanied by the generation of singlet oxygen. BALB/c mice infected with MRSA and treated with quercetin exhibited a reduced bacterial load in the draining lymph nodes and decreased recruitment of polymorphonuclear cells at the infection site. In response to infection, a strong interaction between the cytokines IL-12 and TNF-α was observed in the groups treated with quercetin. These observations support quercetin's anti-inflammatory and antimicrobial potential in infections with resistant strains of MRSA.

Indexed as

Anti-Bacterial AgentsMethicillin-Resistant Staphylococcus aureusPhotochemotherapyPhotosensitizing AgentsQuercetinStaphylococcal InfectionsAnimalsBacterial LoadDisease Models, AnimalFemaleInterleukin-12MiceMice, Inbred BALB CTumor Necrosis Factor-alphaAnti-Bacterial AgentsInterleukin-12Photosensitizing AgentsQuercetinTumor Necrosis Factor-alphaantimicrobial photodynamic therapyphotosensitizerquercetinStaphylococcus aureus

Identifiers

PMID41841172
PMCPMC13140255

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.