ArticleJournal of clinical biochemistry and nutrition2026
A novel rapid technique for quantifying serum oxidized albumin in a mouse model of chronic kidney disease.
Article in Journal of clinical biochemistry and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Oxidative stress serves as both a precursor to and consequence of numerous pathological conditions; however, its assessment remains technically challenging and often imprecise. In the current investigation, we established a rapid high-performance liquid chromatography (HPLC)-based method for quantifying serum oxidized albumin in a murine model of chronic kidney disease (CKD). We optimized the HPLC protocol specifically for measuring oxidized albumin in mice. To validate our methodology, C57BL/6J mice underwent 5/6 nephrectomy (5/6Nx) and were randomly allocated to one of three dietary regimens: standard diet, high-salt diet, or high-salt diet supplemented with Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-
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