ArticleCureus2026
Maternal Morbidity and Complications in Hemolysis, Elevated Liver Enzymes, and Low Platelet Count (HELLP) Syndrome: A Retrospective Case Series.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Background HELLP syndrome (Hemolysis, Elevated Liver Enzymes, and Low Platelets) is a severe obstetric complication associated with significant maternal morbidity and mortality. While its epidemiology is well-described in high-resource settings, data from conflict-affected and resource-limited regions like Afghanistan are critically scarce. This study aimed to delineate the incidence, risk profiles, complications, and outcomes of HELLP syndrome at a major tertiary healthcare hospital. Methodology A retrospective, descriptive case series was conducted at Rabia Balkhi Hospital in Kabul, reviewing all obstetric admissions from January 1 to December 31, 2022. Among 29,633 admissions, 26 patients met the inclusion criteria for HELLP syndrome based on established laboratory parameters (LDH >600 U/L, AST >70 U/L, platelets <100,000/mm³). Data on demographics, clinical presentation, risk factors, complications, and maternal outcomes were extracted and analyzed using descriptive statistics. Results The incidence of HELLP syndrome was 26 cases (0.09%) of all obstetric admissions. The most prevalent risk factors were abruptio placentae (10, 38.5%), diabetes mellitus (5, 19.2%), and chronic hypertension (4, 15.4%). Major maternal complications included disseminated intravascular coagulation (5, 19.2%), renal failure (4, 15.4%), and pulmonary edema (3, 11.5%). Notably, subcapsular liver hematoma, a rare but often fatal complication, was present in two cases (7.7%). The maternal mortality rate was 7.7% (
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