ArticleTranslational animal science2026
Impact of low-crude protein and insoluble fiber diets on post-weaning diarrhea, growth performance, intestinal morphology, and gene expression for nursery pigs with natural rotavirus and subject to enterotoxigenic
Article in Translational animal science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This study evaluated the impact of low‑crude protein (LCP) and insoluble fiber (FIB) diets on post‑weaning diarrhea, intestinal damage, and growth in nursery pigs naturally infected with rotavirus and challenged with enterotoxigenic Escherichia coli F18 (ETEC). A total of 240 pigs were randomly assigned to 40 pens (6 pigs/pen) for a 42-d experiment. Pens were randomly assigned to one of five diets: NC (standard nursery diet without zinc oxide, ZnO, or carbadox); PC (NC + 3,750 mg/kg ZnO and 50 mg/kg carbadox); LCP (NC with reduced crude protein and SID Lys); FIB (NC + 8% wheat middlings); and ZINC (NC + 3,750 mg/kg ZnO). Experimental diets were fed in two phases: phase 1 (d 0-7) and phase 2 (d 7-21) and phase 3 (d 21-42) was a common diet for all pigs. Pigs were positive for rotavirus (strains A, B, and C) within the first week post-wean. To model late nursery outbreaks, pigs were orally inoculated with a field strain of ETEC on day 14-, or 0-d post-inoculation (DPI 0). Scour scores were recorded daily for the first 28 d (-14 to 14 DPI). Body weight (BW), average daily gain (ADG), feed disappearance (ADFI), and feed efficiency (G: F) were evaluated for four periods: DPI -14 to -7; -7 to 0; 0 to 7; 7 to 28. Sample pigs were confirmed to be susceptible to ETEC (FUT1
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