Evidence map›Paper›PMID 41841030›Full record

ArticleInnovation discovery2026

Increased Urinary Albumin Excretion But Less Damaged Renal Tubular Structures in Mice with Genetically Decreased

Meitong Chen, Qing Ma, Niroshani M W Wariyapperuma Appuhamillage, Yuye Wang, Yukako Kayashima, Nobuyo Maeda-Smithies, Feng Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Innovation discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. METTL16 Promotes Cerebral Ischemia-Reperfusion Injury via mInternational journal of general medicine · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Meitong ChenDepartment of Pathology and Laboratory Medicine, School of Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Qing MaDepartment of Pathology and Laboratory Medicine, School of Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Niroshani M W Wariyapperuma AppuhamillageDepartment of Pathology and Laboratory Medicine, School of Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Yuye WangDepartment of Pathology and Laboratory Medicine, School of Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Yukako KayashimaDepartment of Pathology and Laboratory Medicine, School of Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Nobuyo Maeda-SmithiesDepartment of Pathology and Laboratory Medicine, School of Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.
Feng LiDepartment of Pathology and Laboratory Medicine, School of Medicine, The University of North Carolina, Chapel Hill, NC 27599, USA.

Funding

MODELS FOR STUDYING THE GENETICS OF HYPERTENSIONR01HL049277 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MAEDA, NOBUYO · 1992 to 2025
$17.5M
Benefits of nicotinamide in placental development and in preeclamsiaR01HD101485 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LI, FENG · 2021 to 2025
$2.1M
NHLBI NIH HHS R01 HL049277NICHD NIH HHS R01 HD101485
6 · The paper itself

Abstract

Renal ischemia/reperfusion injury (IRI) is a leading cause of acute kidney injury (AKI), a potentially fatal syndrome characterized by a rapid decline in kidney function. The major cause of AKI is IRI. Our prior studies have demonstrated that genetically increased Elmo1 expression in mice aggravated several kidney pathologies including diabetic nephropathy and transition of AKI to chronic kidney disease induced by IRI. However, the effects of decreased expression of Elmo1 on IRI is unclear. We compared the kidney structures and functions between wild type (WT) mice and mice with genetically decreased Elmo1 expression (

Indexed as

ischemia reperfusion injurylow Elmo1 expressionmice

Identifiers

PMID41841030
PMCPMC12989112

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.