Evidence map›Paper›PMID 41840912›Full record

ArticleJournal of cardiovascular electrophysiology2026

Impact of Curarization on Pentaspline Catheter Stability During Pulsed-Field Pulmonary Vein Ablation.

Aymeric Menet, Suzanne Charkaluk, William Escande, Antoine Noel, Outteryck François, Corentin Chaumont, Valentine Pecriaux, Jeremy Layec, Marie Decroocq, Yves Guyomar and 4 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiovascular electrophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Aymeric MenetLaboratoire ETHICS, Groupement des Hôpitaux de l'institut Catholique de Lille, Service de Cardiologie USIC, Université Catholique de Lille, Lille, France.
Suzanne CharkalukLaboratoire ETHICS, Groupement des Hôpitaux de l'institut Catholique de Lille, Service de Cardiologie USIC, Université Catholique de Lille, Lille, France.
William EscandeCentre Cardiologique du Nord, Service de Cardiologie, Saint-Denis, France.
Antoine NoelPolyclinique Saint Laurent, Service de Cardiologie, Rennes, France.
Outteryck FrançoisLaboratoire ETHICS, Groupement des Hôpitaux de l'institut Catholique de Lille, Service de Cardiologie USIC, Université Catholique de Lille, Lille, France.
Corentin ChaumontDepartment of Cardiology, Univ Rouen Normandie, Inserm U1096, CHU Rouen, Rouen, France.
Valentine PecriauxLaboratoire ETHICS, Groupement des Hôpitaux de l'institut Catholique de Lille, Service de Cardiologie USIC, Université Catholique de Lille, Lille, France.ORCID 0009-0003-5684-1298
Jeremy LayecLaboratoire ETHICS, Groupement des Hôpitaux de l'institut Catholique de Lille, Service de Cardiologie USIC, Université Catholique de Lille, Lille, France.
Marie DecroocqLaboratoire ETHICS, Groupement des Hôpitaux de l'institut Catholique de Lille, Service de Cardiologie USIC, Université Catholique de Lille, Lille, France.
Yves GuyomarLaboratoire ETHICS, Groupement des Hôpitaux de l'institut Catholique de Lille, Service de Cardiologie USIC, Université Catholique de Lille, Lille, France.
Vincent ColasLaboratoire ETHICS, Groupement des Hôpitaux de l'institut Catholique de Lille, Service de Cardiologie USIC, Université Catholique de Lille, Lille, France.
Sylvestre MaréchauxLaboratoire ETHICS, Groupement des Hôpitaux de l'institut Catholique de Lille, Service de Cardiologie USIC, Université Catholique de Lille, Lille, France.
Frederic AnselmeDepartment of Cardiology, Univ Rouen Normandie, Inserm U1096, CHU Rouen, Rouen, France.
Guillaume ViartLaboratoire ETHICS, Groupement des Hôpitaux de l'institut Catholique de Lille, Service de Cardiologie USIC, Université Catholique de Lille, Lille, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPulsed field ablation (PFA) is effective for pulmonary vein isolation (PVI), but phrenic nerve stimulation during applications may induce diaphragmatic contractions and destabilize catheter positioning. This study evaluated whether neuromuscular blockade improves catheter stability.

methodsSeventy-six patients undergoing PFA under general anesthesia were prospectively enrolled across three centers. Curarization was assessed using train-of-four (TOF). Catheter motion was measured fluoroscopically, including diaphragmatic excursion, lateral displacement, axial entry into the vein, and inadvertent venous intubation.

resultsSixty-five patients (85%) received curare. In right pulmonary veins, catheter and diaphragmatic motion increased progressively with higher TOF. Compared with TOF 0, absence of curare resulted in greater diaphragmatic excursion, increased lateral and axial catheter movement, and more frequent venous intubation (all p < 0.001). Higher TOF (≥ 4) remained an independent predictor of excessive motion. Left-sided veins showed limited motion across TOF levels.

conclusionInadequate neuromuscular blockade is strongly associated with catheter instability during right-sided PFA. Maintaining TOF ≤ 3 improves stability and may enhance procedural safety. Larger studies are needed to assess long-term impact.

Indexed as

Atrial FibrillationCatheter AblationDiaphragmPulmonary VeinsAgedFemaleHumansMaleMiddle AgedPhrenic NerveProspective StudiesTreatment Outcomeatrial fibrillationcatheter movementcurarediaphragmatic contractionpulsed field ablation

Identifiers

PMID41840912
PMCPMC13269845

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.