Evidence map›Paper›PMID 41840861›Full record

ArticleImmunity, inflammation and disease2026

ALKBH5-Driven m6A Demethylation Boosts Inflammation and Autophagy in LPS-Stimulated Macrophages.

Gui Wang, Ting Zhou, Shujun Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunity, inflammation and disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gui WangDepartment of Critical Care Medicine, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Ting ZhouDepartment of Critical Care Medicine, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, China.
Shujun ZhouDepartment of Critical Care Medicine, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou, China.ORCID https://orcid.org/0009-0006-4182-4921

Funding

Changzhou Sci&Tech Program CJ20252034The Science and Technology Program of Changzhou Health Commission QN202202The Top Talent of Changzhou "The 14th 5-Year Plan" High-Level Health Talents Training Project 2022CZBJ020
6 · The paper itself

Abstract

purposeAcute Respiratory Distress Syndrome (ARDS) remains a critical health threat with limited pharmacological treatments. This study investigates the role of the N

methodsPrimary mouse alveolar macrophages were stimulated with Lipopolysaccharide (LPS) and transfected with ALKBH5 knockdown or overexpression plasmids. Global m6A levels were assessed via Dot Blot, while m

resultsALKBH5 was found to be a critical regulator of m

conclusionsOur findings demonstrate that ALKBH5-driven m

Indexed as

AdenosineAlkB Homolog 5, RNA DemethylaseAutophagyInflammationMacrophages, AlveolarRespiratory Distress SyndromeAnimalsAutophagy-Related Protein-1 HomologCells, CulturedDemethylationDisease Models, AnimalEpitranscriptomeLipopolysaccharidesMaleMiceMice, Inbred C57BLAdenosineALKBH5 protein, mouseAlkB Homolog 5, RNA DemethylaseAutophagy-Related Protein-1 HomologLipopolysaccharidesN-methyladenosineUlk1 protein, mouseAcute respiratory distress syndromeAlkB homolog 5alveolar macrophageinflammatory responseN6‐methyladenosine

Identifiers

PMID41840861
PMCPMC13097382

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.