Evidence map›Paper›PMID 41840818›Full record

ArticleACS synthetic biology2026

Engineering the ADDomer Nanoparticle Vaccine Scaffold for Improved Assembly and Enhanced Stability.

Georgia Balchin, Burak V Kabasakal, Alessandro Strofaldi, Sophie Hall, Charlotte Fletcher, Dora Buzas, Joshua C Bufton, Sathish K N Yadav, Dakang Shen, Frederic Garzoni and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS synthetic biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Georgia BalchinSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, U.K.
Burak V KabasakalSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, U.K.ORCID 0000-0003-3001-9282
Alessandro StrofaldiSchool of Physics, University of Bristol, Tyndall Avenue, Bristol BS8 1TL, U.K.ORCID 0000-0002-8762-4697
Sophie HallSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, U.K.
Charlotte FletcherSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, U.K.
Dora BuzasSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, U.K.
Joshua C BuftonSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, U.K.
Sathish K N YadavSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, U.K.
Dakang ShenSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, U.K.
Frederic GarzoniSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, U.K.
H Adrian BunzelSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, U.K.
Jennifer J McManusSchool of Physics, University of Bristol, Tyndall Avenue, Bristol BS8 1TL, U.K.ORCID 0000-0003-3630-5108
Christiane SchaffitzelSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, U.K.
Imre BergerSchool of Biochemistry, University of Bristol, University Walk, Bristol BS8 1TD, U.K.ORCID 0000-0001-7518-9045

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Virus-like particles (VLPs) are promising platforms for next-generation vaccines due to their ability to present antigens in highly ordered, repetitive geometries emulating pathogen-associated patterns to elicit potent immune responses. The ADDomer is a synthetic dodecahedral VLP scaffold derived from the penton base protein (PBP) of human adenovirus serotype 3 (Ad3). PBP tolerates insertion of multiple antigenic epitopes in flexible surface-exposed loops, and spontaneously self-assembles

Indexed as

NanoparticlesVaccines, Virus-Like ParticleAdenoviruses, HumanAnimalsCapsid ProteinsCryoelectron MicroscopyEpitopesHumansNanovaccinesProtein EngineeringProtein Subunit VaccinesCapsid ProteinsEpitopesNanovaccinesProtein Subunit VaccinesVaccines, Virus-Like ParticleAdenovirusElectron cryo-microscopy (cryo-EM)Nanoparticle vaccinesProtein engineeringThermostabilityVirus-like particles (VLPs)

Identifiers

PMID41840818
PMCPMC13097255

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.