Observational studyInterdisciplinary cardiovascular and thoracic surgery2026
Prolonged Systemic Inflammatory Response Syndrome Predicts Atrial Fibrillation After Cardiac Surgery.
Observational study in Interdisciplinary cardiovascular and thoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03444259 (Cardiovascular Research Consortium - a Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cardiovascular Research Consortium - a Prospective Project to Identify Biomarkers of Morbidity and Mortality in Cardiovascular Interventional Patients
Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
objectivesCardiac surgery and the use of cardiopulmonary bypass (CPB) lead to short-lasting postoperative inflammatory response and some patients fail to adapt to the stress leading to a prolonged systemic inflammatory response syndrome (SIRS). We aimed to identify the risk factors for prolonged SIRS and whether this may affect the onset of short- and long-term postoperative atrial fibrillation (AF) after adult cardiac surgery patients.
methodsThe CAREBANK biobank study consists of prospectively enrolled patients undergoing adult cardiac surgery from 2016 to 2021 with ongoing follow-up data. This substudy included patients operated on with or without the use of CPB.
resultsOverall, 982 patients underwent cardiac surgery, 824 (84%) patients using CPB. Prolonged SIRS was observed in 62 (6.3%) patients. Transfusion of packed red blood cells (OR 1.9, 95%, confidence interval [CI] 1.1-3.5, P = .03), and the first postoperative day C-reactive protein level (OR 1.2, 95%, CI 1.0-1.3, per 10 units, P = .002) were associated with the development of prolonged SIRS in a multivariable analysis. Patients with prolonged SIRS had more adverse events during index hospitalization, mainly driven by the higher incidence of postoperative AF compared to non-SIRS patients (OR 2.4, 95%, CI, 1.4-4.0, P < .001). At 2 years, the incidence of post-discharge AF was higher compared with non-SIRS patients (hazard ratio 2.0, 95% CI, 1.1-3.6, P = .024).
conclusionsA subset of cardiac surgery patients demonstrates impaired adaptation to the perioperative inflammatory response, placing them at increased risk for AF both early after surgery and following discharge. CLINICAL REGISTRATION NUMBER: NCT03444259.
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