ArticleChinese medicine2026
Online real-time mass spectrometry-driven dynamic monitoring and optimal endpoint prediction schema development for herbal medicine decoction process.
Article in Chinese medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundThe decoction process of compound formulae is a critical procedure in traditional herbal medicine for reducing toxicity and preserving efficacy. However, due to the high complexity of herb ingredients and chemical constituents in the formulae, precise real-time monitoring of the dynamic changes in the decoction system and accurately predicting its optimal endpoint remain significant challenges that current technologies struggle to address. PURPOSE: To develop an online real-time mass spectrometry (ORT-MS)-driven strategy for real-time monitoring complex components during the decoction of compound formulae, and to establish a validated schema for predicting the optimal decoction endpoint, using Zhenwu Decoction as a case study.
resultsA novel ORT-MS monitoring device was established successfully, enabling continuous long-term (> 240 min) MS monitoring of various compounds in Zhenwu Decoction. By quantitatively tracking the decoction profiles of key toxic (e.g., hypaconitine) and bioactive (e.g., benzoylhypaconitine) compounds, a method for evaluating overall toxicity/bioactivity of the decoction was built. Furthermore, a comprehensive schema for determining the optimal decoction endpoint was proposed, integrating five-dimension: safety, bioactivity, time, energy consumption, and financial cost (SBTEF). The results demonstrated, under the experimental conditions and dosage adopted in this study, that the optimal decoction endpoint for Zhenwu Decoction is about 150 min when all factors are considered.
conclusionThis study proposes a universal MS-driven real-time analysis strategy and endpoint prediction schema for herbal medicine decoction process, providing a novel scientific tool for decoction quality evaluation (especially toxicity attenuation/efficacy preservation) to promote herbal medicine quality and rational clinical use.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.