Evidence map›Paper›PMID 41840626›Full record

ArticleBMC medicine2026

SPP1

Shuai Zhao, Xiumeng Hua, Dongxing Zhu, Peiyuan Li, Hao Cui, Zhe Sun, Yifan Wang, Yiqi Zhao, Xingyue Yang, Weiteng Wang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Shuai Zhao *School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511495, Guangdong, China.
Xiumeng Hua *Beijing Key Laboratory of Xenotransplantation, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China. huaxiumeng@163.com.
Dongxing Zhu *Beijing Key Laboratory of Xenotransplantation, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Peiyuan LiBeijing Key Laboratory of Xenotransplantation, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Hao CuiBeijing Key Laboratory of Xenotransplantation, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Zhe SunShenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen, 518057, China.
Yifan WangBeijing Key Laboratory of Xenotransplantation, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Yiqi ZhaoBeijing Key Laboratory of Xenotransplantation, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Xingyue YangShenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen, 518057, China.
Weiteng WangBeijing Key Laboratory of Xenotransplantation, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Yijing LiBeijing Key Laboratory of Xenotransplantation, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Hang ZhangBeijing Key Laboratory of Xenotransplantation, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Han MoBeijing Key Laboratory of Xenotransplantation, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Fei DongShenzhen Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Shenzhen, 518057, China.
Yuanping GuBeijing Key Laboratory of Xenotransplantation, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Xiao ChenBeijing Key Laboratory of Xenotransplantation, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China.
Xiaodong FuSchool of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511495, Guangdong, China. fuxiaod@gzhmu.edu.cn.
Jiangping SongSchool of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511495, Guangdong, China. fwsongjiangping@126.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypertension-associated aortic dissection (HTN-AD) features intense immune activation and extracellular matrix disruption, yet the cellular programs that promote aortic-wall stabilization remain unclear. We aimed to identify macrophage states associated with vascular integrity and to determine whether these states could be mechanistically or therapeutically leveraged.

methodsSingle-cell RNA sequencing was performed on thoracic aortas from HTN-AD, Marfan syndrome-associated AD, and donor controls (n = 3 per group). Peripheral and tear-adjacent blood samples were analyzed in patients with HTN-AD, MS-AD, and healthy donors (n = 30 per group), with paired intraoperative tear-adjacent sampling performed when available (n = 10). Circulating monocytes and serum cytokines were profiled by flow cytometry and ELISA. Functional validation included TGF-β1 conditioning of human monocytes and murine macrophages and adoptive transfer experiments in a murine AD model.

resultsA distinct SPP1

conclusionsA TGF-β1-SPP1 axis drives the emergence of SPP1

Indexed as

Aortic DissectionHypertensionMacrophagesOsteopontinVascular RemodelingAdultAnimalsAorta, ThoracicDissection, Thoracic AortaFemaleFibrosisHumansMaleMiceMice, Inbred C57BLMiddle AgedOsteopontinSPP1 protein, humanTransforming Growth Factor beta1Aortic dissectionFibrosisMacrophageSPP1 (osteopontin)TGF-β1

Identifiers

PMID41840626
PMCPMC13104576

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.