ArticleItalian journal of pediatrics2026
Functional study of peripheral blood CD8 + T cells in Epstein-Barr virus-associated infectious mononucleosis.
Article in Italian journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Epstein-Barr virus reactivation triggers selective IL-6/IL-10 axis inflammation and CD3Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aimed to explore the function and clinical significance of peripheral blood CD8 + T cells in EBV-associated infectious mononucleosis (IM).
methodsFrom June 2022 to May 2024, blood samples of 48 IM children and 24 healthy controls were collected. ELISA detected IFN-γ, IL-10, TGF-β1 levels, and RT-PCR measured perforin and granzyme B mRNA levels.
resultsresults showed higher white blood cell, lymphocyte counts, etc. in the case group. Also, more CD3+, CD3 + CD8+ and NK cells, lower CD4+/CD8 + ratio were found in cases. IFN-γ, IL-10, perforin, granzyme B were higher, while TGF-β1 was lower in cases. Some negative and positive correlations were found among cytokines and cell counts.
conclusionCD8 + T cells and their related cytokines IFN-γ, IL-10, TGF-β1, perforin and granzyme B are involved in the immune process of infectious mononucleosis related to EBV. CLINICAL TRIAL NUMBER: Not applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.