Evidence map›Paper›PMID 41840606›Full record

ArticleJournal of nanobiotechnology2026

Multi-functional self-powered nanofiber conduit for peripheral nerve regeneration and muscle atrophy prevention.

Renjie Tan, Ke Zhang, Yifan Si, Kaisong Huang, Weibin Jia, Min Li, Saira Iqbal, Shuai Zhang, Zhenya Zhai, Jinlian Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Renjie TanJiangxi Provincial Engineering Research Center for High-Throughput Screening and Evaluation of Small Molecule Compounds, Institute of Medicine and Health, Jiangxi Academy of Sciences, Nanchang, 330096, Jiangxi, China.
Ke ZhangDepartment of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong SAR, China.
Yifan SiCollege of Biomass Science and Engineering, Sichuan University, Chengdu, 610065, P. R. China.
Kaisong HuangDepartment of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong SAR, China.
Weibin JiaState Key Laboratory of Transvascular Implantation Devices, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310053, China.
Min LiDepartment of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong SAR, China.
Saira IqbalDepartment of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong SAR, China.
Shuai ZhangDepartment of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong SAR, China.
Zhenya ZhaiJiangxi Provincial Engineering Research Center for High-Throughput Screening and Evaluation of Small Molecule Compounds, Institute of Medicine and Health, Jiangxi Academy of Sciences, Nanchang, 330096, Jiangxi, China. zhaizhenyascau@163.com.
Jinlian HuDepartment of Biomedical Engineering, City University of Hong Kong, Kowloon, 999077, Hong Kong SAR, China. jinliahu@cityu.edu.hk.

Funding

CityU Startup Grant Grant 9380116Contract Research CityU ref: 9231419National Natural Science Foundation of China (NSFC) Grant 52073241; Grant 51673162; Grant 15201719
6 · The paper itself

Abstract

Peripheral nerve injury (PNI) often leads to limited functional recovery in over 50% of patients, with current clinical strategies primarily relying on nerve grafts or conduits to bridge injury gaps. In the search of alternative solutions, self-powered biomaterials show significant potential in tissue engineering applications. This study designed a self-powered polycaprolactone/gelatin (PCL/gelatin) nanofiber conduit for sciatic nerve regeneration. The electrospun PCL/gelatin nanofiber conduit was characterized for its self-powering capability, mechanical strength, biocompatibility, and degradability. Functionalization of the nanofiber conduit with conductive polypyrrole (PPy) nanoparticles loaded with nonsteroidal anti-inflammatory drugs (NSAIDs) enhanced anti-inflammatory and antioxidative effects and helped prevent muscle atrophy. Furthermore, the incorporation of conductive polymers reduced polarization cancellation and enabled the controlled release of NSAIDs through exercise-induced mechanical stimulation of the nanofiber conduit. Transcriptomic analyses confirmed that the nanofiber conduit promoted peripheral nerve regeneration and inhibited apoptosis by activating insulin signaling.

Indexed as

Muscular AtrophyNanofibersNerve RegenerationPeripheral Nerve InjuriesAnimalsAnti-Inflammatory Agents, Non-SteroidalBiocompatible MaterialsGelatinPolyestersPolymersPyrrolesRatsSciatic NerveTissue EngineeringTissue ScaffoldsAnti-Inflammatory Agents, Non-SteroidalBiocompatible MaterialsGelatinpolycaprolactonePolyestersPolymerspolypyrrolePyrrolesDrug deliveryMuscle atrophyNanofiber conduitNerve repairSelf-powered

Identifiers

PMID41840606
PMCPMC13104470

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.