Evidence map›Paper›PMID 41840561›Full record

Trial reportBMC palliative care2026

Feasibility and acceptability of "LiCPain" pilot randomised controlled trial of continuous subcutaneous infusion of lidocaine or placebo for people with neuropathic cancer pain: a qualitative study of patient and carer perceptions and experiences.

Jessica T Lee, Meera Agar, Jane L Phillips, Angela Rao, Emily Huang, Megan Ritchie, Belinda Fazekas, Priyanka Vandersman, Ghauri Aggarwal, Dipti Mittal and 15 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC palliative care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Jessica T LeeImproving Palliative, Aged and Chronic Care Through Clinical Research and Translation (IMPACCT), Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia. jessica.lee1@health.nsw.gov.au.
Meera AgarImproving Palliative, Aged and Chronic Care Through Clinical Research and Translation (IMPACCT), Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia.
Jane L PhillipsImproving Palliative, Aged and Chronic Care Through Clinical Research and Translation (IMPACCT), Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia.
Angela RaoSchool of Nursing, College of Health and Medicine, University of Tasmania, Sydney, NSW, Australia.
Emily HuangConcord Centre for Palliative Care, Concord Repatriation General Hospital, Concord, NSW, Australia.
Megan RitchieConcord Centre for Palliative Care, Concord Repatriation General Hospital, Concord, NSW, Australia.
Belinda FazekasImproving Palliative, Aged and Chronic Care Through Clinical Research and Translation (IMPACCT), Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia.
Priyanka VandersmanResearch Centre for Palliative Care, Death and Dying, Flinders University, Adelaide, South Australia, Australia.
Ghauri AggarwalConcord Centre for Palliative Care, Concord Repatriation General Hospital, Concord, NSW, Australia.
Dipti MittalConcord Centre for Palliative Care, Concord Repatriation General Hospital, Concord, NSW, Australia.
Caitlin SheehanPalliative Care, Calvary Healthcare, Kogarah, NSW, Australia.
Rajesh AggarwalPalliative Care, South West Sydney Local Health District, Bankstown, NSW, Australia.
Davinia SeahSacred Heart Supportive & Palliative Care, St Vincent's Hospital Sydney, Darlinghurst, NSW, Australia.
Marian KowPharmacy, Concord Repatriation General Hospital, Concord, NSW, Australia.
Rachel GeorgePharmacy, Concord Repatriation General Hospital, Concord, NSW, Australia.
Richard ChyeImproving Palliative, Aged and Chronic Care Through Clinical Research and Translation (IMPACCT), Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia.
Anthony LintonConcord Clinical School, University of Sydney, Concord, NSW, Australia.
Bev NobleConsumer Representative, Improving Palliative, Aged and Chronic Care Through Clinical Research and Translation (IMPACCT), Faculty of Health, University of Technology Sydney, Sydney, NSW, Australia.
David CurrowFlinders Ageing Alliance, Flinders University, Bedford Park, South Australia, Australia.
Chadi AyoubCardiovascular Medicine, Mayo Clinic, Scottsdale, AZ, USA.
Kat UrbanPalliative Care, Northern NSW Local Health District, Lismore, NSW, Australia.
Christine SandersonTerritory Palliative Care - Central Australia, Alice Springs, Northern Territory, Australia.
Belinda E ButcherWriteSource Medical Pty Ltd, North Sydney, New South Wales, Australia.
Andrew McLachlanSydney Pharmacy School, The University of Sydney, Sydney, NSW, Australia.
Melanie R LovellHammondCare, Greenwich Palliative and Supportive Care Services, Sydney, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOptimal intervention and clinical trial designs require consumer contributions. The experience of people with advanced cancer and palliative care needs in neuropathic pain trials is seldom reported.

methodsThis exploratory descriptive qualitative sub-study aimed to understand the experience of patients and carers participating in the Lidocaine for Neuropathic Cancer Pain (LiCPain) study, a pilot randomised controlled trial of continuous subcutaneous infusion of lidocaine hydrochloride or placebo over 72 h in people with unrelieved neuropathic cancer pain. All participants enrolled in the trial, conducted at five Australian palliative care inpatient sites, were intended to be invited to participate at the time of consenting to the main study. Reasons for not being invited, consenting to or completing the interview sub-study were not collected. A single face-to-face or telephone interview was audio recorded by the site study team nurses or doctors using a semi-structured interview guide. Data were analysed following Braun and Clarke thematic analysis approach.

resultsOut of 17 participants randomised to the LiCPain trial, seven participants and one carer consented to participate in the qualitative sub-study. Three major themes were identified: • Trial participation offered a sense of hope and purpose; • The impact of the intervention has multiple contributing factors; and • Pain impacts every aspect of life.

conclusionsParticipants found hope and purpose in the Lidocaine for Neuropathic Cancer Pain trial. Contextual factors influenced perceived effectiveness. These findings will inform future intervention designs and clinical trials to improve outcomes for people experiencing unrelieved neuropathic cancer pain.

trial registrationThis trial was registered in the Australian New Zealand Clinical Trials Registry (ACTRN12617000747325) on 22nd May 2017.

Indexed as

Cancer PainCaregiversLidocaineNeuralgiaPatientsPerceptionAdultAgedAged, 80 and overAnesthetics, LocalAustraliaFeasibility StudiesFemaleHumansInfusions, SubcutaneousMaleAnesthetics, LocalLidocaineCancerExperienceHopeImpactNeuropathicPainPalliativePurposeRecruitmentTrials

Identifiers

PMID41840561
PMCPMC13107867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.