ArticleBMC women's health2026
Factors associated with hysterectomy after failure of levonorgestrel-releasing intrauterine system treatment in women with abnormal uterine bleeding.
Article in BMC women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Adenomyosis and Endometrial Polyps: A Systematic Review of Coexistence Patterns and Diagnostic Contexts.International journal of women's health · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbnormal uterine bleeding (AUB) is a common gynecological condition with a significant impact on women’s quality of life and public health. Although the levonorgestrel-releasing intrauterine system (LNG-IUS) is an effective first-line treatment, a subset of women ultimately require hysterectomy. The demographic, clinical, ultrasonographic, and histopathological factors associated with LNG-IUS treatment failure remain insufficiently understood.
methodsThis retrospective descriptive study included 233 women diagnosed with AUB who underwent LNG-IUS (Mirena®) insertion between November 2019 and December 2022 at a tertiary referral center. Patients were divided into two groups according to hysterectomy status during follow-up. Demographic data, PALM–COEIN classification, ultrasonographic findings, and histopathological results were analyzed.
resultsOf the 233 women, 60 (25.7%) underwent hysterectomy due to treatment-resistant bleeding, while 173 (74.2%) were managed successfully without surgery. Women in the hysterectomy group were significantly older than those in the non-hysterectomy group (median age 45.35 vs. 41.76 years, p = 0.001). Body mass index and parity did not differ significantly between groups. Structural uterine pathology was present in 92% of patients who required hysterectomy. Leiomyoma was the most common histopathological finding (38.3%), followed by adenomyosis (21.7%). Combined pathologies, including adenomyosis with leiomyoma or endometrial polyps, were also frequent. By contrast, most women in the non-hysterectomy group had no identifiable structural uterine abnormalities.
conclusionThe effectiveness of the LNG-IUS in AUB management is strongly influenced by underlying structural uterine pathology. Leiomyoma and adenomyosis, particularly when coexisting, are major predictors of treatment failure and subsequent hysterectomy. Careful pre-treatment evaluation and individualized counseling are essential to optimize patient selection and treatment outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.