SynthesisBMC anesthesiology2026
The effect of esketamine on emergence delirium or agitation in children after anesthesia-a systematic review and meta-analysis.
Synthesis in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis systematic review and meta-analysis aim to evaluate esketamine on emergence delirium or emergence agitation (ED/EA) in pediatric children in contrast to the control group.
methodsThe PubMed, Web of Science, and Cochrane Library databases were systematically searched until August 2024, employing inclusion criteria focused on studies involving children under the age of 18 comparing esketamine to control groups. The exclusion criteria encompassed participants aged 18 years and older, reviews or meta-analyses, fundamental animal studies, articles published solely in abstract form, letters to the editor, case reports, editorial notes, methodological protocols, and publications not in English.
resultsA total of 1142 children were included in ten randomized controlled trials (RCTs) and one cohort study, revealing that esketamine significantly reduces the risk of ED/EA in pediatric patients following surgery when compared to the control group (OR = 0.70, 95% CI: (0.51, 0.97), I
conclusionsIn comparison to the control group, esketamine significantly decreases the incidence of emergence delirium or emergence agitation (ED/EA) in pediatric patients, with a markedly lower heterogeneity (I
trial registrationProspero registration ID:CRD42024583287. Link:PROSPERO (york.ac.uk).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.