Evidence map›Paper›PMID 41840451›Full record

ArticleBMC sports science, medicine & rehabilitation2026

PRICE (Protection, Rest, Ice, Compression, Elevation) vs. PEACE and LOVE (Protection, Elevation, Avoid anti-inflammatories, Compression, Education and Load, Optimism, Vascularization, Exercise) in adolescent lateral ankle sprain rehabilitation: a randomized prospective comparative study of muscle strength and dynamic balance.

Matas Meškauskas, Saulius Rutkauskas, Miglė Misiūnienė, Juozas Žumbakys, Jūratė Tomkevičiūtė, Dalius Malcius, Emilis Čekanauskas

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In one paragraph

Article in BMC sports science, medicine & rehabilitation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07287020 (PRICE vs PEACE and LOVE in Adolescent Lateral Ankle Sprain Rehabilitation), which is not on this map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07287020 nacompletednot on this map

PRICE vs PEACE and LOVE in Adolescent Lateral Ankle Sprain Rehabilitation: a Prospective Comparative Study of Muscle Strength and Dynamic Balance.

TypeinterventionalSponsorLithuanian University of Health SciencesRan2022 to 2025Enrolled76ConditionsLateral Ankle Sprain, Ankle Injuries, Sprain of Lateral Ligament, Rupture of Ligaments at Ankle and Foot LevelArmsPRICE + NSAIDs protocol, PEACE and LOVE protocol
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Matas MeškauskasDepartment of Pediatric Surgery, Lithuanian University of Health Sciences, Kaunas, LT-44307, Lithuania. matas.meskauskas@lsmu.lt.
Saulius RutkauskasDepartment of Radiology, Lithuanian University of Health Sciences, Kaunas, LT-44307, Lithuania.
Miglė MisiūnienėDepartment of Sports Medicine, Lithuanian University of Health Sciences, Kaunas, LT-44307, Lithuania.
Juozas ŽumbakysMedical academy, Lithuanian University of Health Sciences, Kaunas, LT-44307, Lithuania.
Jūratė TomkevičiūtėDepartment of Physics, Mathematics and Biophysics, Lithuanian University of Health Sciences, Kaunas, LT-44307, Lithuania.
Dalius MalciusDepartment of Pediatric Surgery, Lithuanian University of Health Sciences, Kaunas, LT-44307, Lithuania.
Emilis ČekanauskasDepartment of Pediatric Surgery, Lithuanian University of Health Sciences, Kaunas, LT-44307, Lithuania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesLAS is common in adolescents, yet early management strategies differ. The traditional PRICE + NSAIDs protocol focuses on short-term symptom relief, whereas the PEACE and LOVE framework emphasizes education, early optimal loading, and progressive exercise. This study compared functional recovery between these two approaches.

methodsA prospective randomized study enrolled 76 adolescents (12–17 years) with first-time LAS, allocated to PRICE + NSAIDs or PEACE and LOVE using a computer-generated randomization sequence with concealed envelope allocation; 65 completed follow-up (PRICE n = 32; PEACE and LOVE n = 33). Functional performance was assessed at 1–2, 5–7, and 12–15 weeks using Biodex isokinetic dynamometry and the Y-Balance Test composite score (YBT-CS). Outcomes were expressed as side-to-side deficits (uninjured − injured limb) and analyzed using two-way mixed repeated-measures analysis of variance, with Group (PRICE + NSAIDs vs. PEACE and LOVE) as the between-subject factor and Time (1–2, 5–7, and 12–15 weeks) as the within-subject factor.

resultsSignificant main effects of time were observed for IN strength at 60°/s (F = 5.73, p = 0.006) and 120°/s (F = 10.15, p < 0.001), EV strength at 120°/s (F = 6.82, p = 0.003), ankle ROM at 60°/s (F = 12.79, p < 0.001) and 120°/s (F = 13.09, p < 0.001), and YBT CS (F = 6.91, p = 0.002), indicating progressive recovery across follow-up. No significant group effects or time × group interactions were detected for any outcome (all p > 0.05).

conclusionsBoth rehabilitation protocols were associated with progressive functional recovery following adolescent LAS. No statistically significant between-group differences or differential recovery trajectories were detected over 12–15 weeks. These findings suggest that an active, education-focused rehabilitation approach yields functional outcomes comparable to traditional PRICE + NSAIDs management in the short term. Larger studies with longer follow-up are required to determine whether clinically meaningful differences exist between protocols.

trial registrationClinicalTrials.gov: NCT07287020; registered 3 December 2025 (retrospectively registered).

Indexed as

Acute lateral ankle ligament injuryAnkle instabilityBiodexLateral ankle sprainPEACE and LOVEPRICEY balance test

Identifiers

PMID41840451
PMCPMC13107599

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.