ArticleBMC public health2026
Mortality trends in older adults (55-84 years) with sepsis-atrial fibrillation: a CDC database analysis.
Article in BMC public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundSepsis is a leading cause of mortality among older adults, and atrial fibrillation (AF), as a common comorbidity, significantly increases the risk of adverse outcomes. This study aimed to investigate nationwide mortality trends, racial and regional disparities, and contributing factors in adults aged 55–84 years with sepsis-AF.
methodsWe analyzed CDC WONDER mortality data for adults aged 55–84 years (1999–2020), defining cases as deaths with sepsis (A40–A41) as the underlying cause and AF (I48) listed as a contributing condition anywhere on the certificate. Individuals aged 55–84 years with sepsis-AF noted on death certificates were included. Age-adjusted mortality rates (AAMR) were calculated based on the 2000 US standard population. Temporal trends in AAMR were assessed using Joinpoint regression, and analyses were stratified by race and geographic region.
resultsThe overall AAMR increased significantly from 0.64 to 1.57 per 100,000 (145% rise; average annual percent change [AAPC] = 4.49%). Marked disparities were observed: males exhibited 30.7% higher mortality than females by 2020; Black individuals showed higher mean AAMR throughout the study period though rates converged statistically by 2020; and the South recorded the highest regional AAMR while the West showed the largest relative increase. AAMR surged across all groups in 2020, coinciding with the COVID-19 pandemic.
conclusionsMortality due to sepsis-AF among older adults aged 55–84 years in the US has exhibited a sustained upward trajectory, accompanied by significant demographic and regional disparities. Targeted public health interventions are essential to address these inequalities and mitigate mortality in high-risk populations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.