ArticleJournal of assisted reproduction and genetics2026
Sperm capacitation ability, as evaluated by Cap-Score™, has little impact on ICSI success.
Article in Journal of assisted reproduction and genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMen with low capacitation ability have reduced conception through intercourse, IUI, and conventional IVF and are often referred for ICSI. This study evaluated whether reduced capacitation ability, as measured by Cap-Score, impacts ICSI outcomes.
methodsRetrospective review of 199 men undergoing ICSI at a single clinic (2018-2023). Semen analysis included Cap-Score. Fertilization and euploidy rates were compared for low vs normal Cap-Scores and abnormal vs normal semen analyses. Following frozen embryo transfer, Cap-Scores and semen analysis outcomes were compared between positive and negative pregnancy indicators. Multiple and logistic regression assessed whether male and female factors, including Cap-Score, independently predicted fertilization, euploidy, hCG positivity, or clinical pregnancy.
resultsFertilization (82 ± 1.9 vs 80 ± 1.6%; p = 0.40) and euploidy rates (43 ± 5.1 vs 34 ± 3.3%; p = 0.13) were similar for those with low vs normal Cap-Scores. Cap-Scores did not differ for negative vs positive hCG (30 ± 1.2 vs 30 ± 1.0%; p = 0.96), clinical pregnancy (30 ± 1.0 vs 30 ± 1.1%; p = 0.83), or ongoing pregnancies/live birth (30 ± 1.0 vs 30 ± 1.1%; p = 0.92). Fertilization and pregnancy outcomes were independent of semen analysis results. Multiple regression showed fertilization was associated only with female age and number of oocytes retrieved (R
conclusionWithin this cohort and analytical framework, no association was detected, supporting the conclusion that men with low Cap-Scores can be counselled that their ICSI outcomes are comparable to those with normal scores.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.