Evidence map›Paper›PMID 41840277›Full record

ArticleMolecular imaging and biology2026

The Binding of the High Affinity Radioligand Fallypride to the D2-dopamine Receptor is Sensitive to Injected Mass - a PET Study in Rodents.

Miklós Tóth, Lenke Tari, Sangram Nag, Tian Qiu, Zhisheng Jia, Jenny Häggkvist, Jogeshwar Mukherjee, Andrea Varrone, Christer Halldin, Lars Farde

Abstract read
In one paragraph

Article in Molecular imaging and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Miklós Tóth *Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, 171 76, Sweden. miklos.toth@ki.se.ORCID 0000-0002-1652-7136
Lenke Tari *Department of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, 171 76, Sweden.
Sangram NagDepartment of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, 171 76, Sweden.
Tian QiuDepartment of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, 171 76, Sweden.
Zhisheng JiaDepartment of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, 171 76, Sweden.
Jenny HäggkvistDepartment of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, 171 76, Sweden.
Jogeshwar MukherjeeDepartment of Radiological Sciences, Preclinical Imaging Center, University of California-Irvine, Irvine, CA, USA.
Andrea VarroneDepartment of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, 171 76, Sweden.
Christer HalldinDepartment of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, 171 76, Sweden.
Lars FardeDepartment of Clinical Neuroscience, Center for Psychiatry Research, Karolinska Institutet and Stockholm County Council, Stockholm, 171 76, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeFallypride is a widely used high affinity radioligand for quantification of D2-dopamine receptor binding in small animal PET imaging. To examine the effect of mass both [ PROCEDURES: Eight mice (C57BL/6 J) went through three PET measurements within two weeks. [

resultsThe binding of [

conclusionIn this PET study in mice the average radioligand occupancy was estimated to 19% even for

Indexed as

BenzamidesPositron-Emission TomographyRadiopharmaceuticalsReceptors, Dopamine D2AnimalsCarbon RadioisotopesDopaminergic ImagingLigandsMaleMiceMice, Inbred C57BLProtein BindingBenzamidesCarbon RadioisotopesfallyprideLigandsRadiopharmaceuticalsReceptors, Dopamine D2D2-dopamine receptorFallyprideMass effectMolar activityMousePositron emission tomography (PET)

Identifiers

PMID41840277
PMCPMC13160952

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.