Evidence map›Paper›PMID 41840234›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Twin-to-twin transfusion syndrome and neonatal acute kidney injury after selective fetoscopic laser photocoagulation.

Evelyn Obregon, Stefanie Riddle, Liu Chunyan, Shelley Ehrlich, Braxton Forde, Meredith P Schuh, Stuart L Goldstein, Cara L Slagle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Evelyn ObregonDivision of Neonatology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45206, USA. evelyn.obregon@cchmc.org.ORCID http://orcid.org/0000-0003-2543-1141
Stefanie RiddleDivision of Neonatology, Perinatal Institute, Cincinnati Children's Hospital Medical Center, 3333 Burnet Ave, Cincinnati, OH, 45206, USA.
Liu ChunyanDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Shelley EhrlichDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Braxton FordeFetal Care Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Meredith P SchuhDivision of Nephrology & Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Stuart L GoldsteinDivision of Nephrology & Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Cara L SlagleDivision of Neonatal-Perinatal Medicine, Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USA.

Funding

College of Medicine, University of Cincinnati UL1TR001425
6 · The paper itself

Abstract

backgroundSelective Fetoscopic Laser Photocoagulation (SFLP) is used to treat Twin-Twin Transfusion Syndrome (TTTS), affecting 10-15% of monochorionic twin pregnancies. Historical data have reported neonatal acute kidney injury (AKI) as high as 50% following TTTS; however, the incidence of AKI following SFLP remains poorly characterized.

methodsWe conducted a single-center retrospective study of monochorionic diamniotic twins who underwent SFLP for TTTS between 2010 and 2023. The primary outcome was the development of AKI during the first two weeks of life, defined by the Neonatal Modified KDIGO criteria. Mixed-effects logistic regression was performed to identify associations with AKI.

resultsAmong 103 infants included, 15 (14.6%) developed AKI. Twins with AKI were born at earlier gestational age (26 weeks vs. 30 weeks, p < 0.001) and had lower birth weights (923 vs. 1320 g, p = 0.01). Adjusted analysis demonstrated longer latency to delivery (OR 0.69, 95% CI 0.54-0.88) and greater total number of arteriovenous (AV) anastomoses (OR 0.78, 95% CI 0.64-0.94) were associated with decreased odds of AKI.

conclusionOur postnatal incidence of AKI following SFLP for TTTS is less common than previously described. Our findings suggest that a more extensive AV anastomotic network and/or longer latency to delivery may allow for improved hemodynamic balance and kidney maturation.

Indexed as

Acute Kidney InjuryFetofetal TransfusionFetoscopyLaser CoagulationPostoperative ComplicationsFemaleGestational AgeHumansIncidenceInfant, NewbornMalePregnancyRetrospective StudiesRisk FactorsLaser therapyNeonatal AKITwin-to-twin transfusion syndrome

Identifiers

PMID41840234
PMCPMC13337727

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