SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Effects of psychosocial interventions on cancer-related fatigue in patients with colorectal cancer: a systematic review and meta-analysis of randomised controlled trials.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis review aimed to scrutinise and critically appraise the evidence on the effects of psychosocial interventions in alleviating CRF for colorectal cancer patients.
methodsMEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Web of Science, CINAHL Ultimate, APA PsycInfo, CNKI, and WANFANG Database were electronically searched from inception to 31st August 2025 for randomised controlled trials examining psychosocial interventions for CRF in colorectal cancer patients. Meta-analyses were performed for short-term (immediately post-intervention to 1 month), medium-term (> 1 to 3 months), and long-term (> 3 months) follow-up periods. The certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. The Review Manager Software (Version 5.4.1) was used for data analysis.
resultsNine studies with 1426 participants were included. Interventions were categorised as psychotherapies, psycho-behavioural interventions, and yoga. Meta-analyses indicated that compared to controls, psychosocial interventions significantly reduced CRF at short-term (standardised mean difference (SMD) = -0.53, 95% confidence interval (CI) = -0.82 to -0.23), medium-term (SMD = -0.51, 95%CI = -0.73 to -0.29), and long-term (SMD = -0.24, 95%CI = -0.46 to -0.01) follow-up. Subgroup analyses indicated that psycho-behavioural interventions were effective (SMD = -0.39, 95% CI = -0.76 to -0.01), while psychotherapy and yoga showed no significant effects. The certainty of evidence ranged from very low to moderate.
conclusionsPsychosocial interventions, particularly psycho-behavioural approaches, appear effective in reducing CRF among patients with colorectal cancer; however, effects were consistent at medium-term and long-term follow-up, while short-term findings showed substantial heterogeneity. More rigorous, adequately powered trials are needed to strengthen and extend the current evidence base.
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