ArticleEye (London, England)2026
Fall-related open globe injuries are associated with systemic health changes.
Article in Eye (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo characterise peri-injury systemic health changes in patients with fall-related open globe injuries (OGIs).
designRetrospective cohort study.
participants162 patients with fall-related OGIs, identified from a cohort of 1016 consecutive OGIs treated at a single academic medical center between 2016 and 2024.
methodsElectronic medical records were reviewed. Patients were included if the injury resulted from a fall and sufficient systemic health data were available.
main outcome measuresIncidence of new systemic diagnoses, disease exacerbations, and medication changes occurring within 90 days before or after the OGI. Specialist visits within the window and one-year mortality data were secondary measures.
resultsOf 1016 OGIs, 223 were fall-related (59.3% female, mean age 73.7 ± 14.3). Of 162 patients meeting inclusion criteria, 103 (63.6%) had at least one new systemic diagnosis likely contributing to the fall. Forty-three patients (26.5%) experienced exacerbation of pre-existing conditions, 28 (65.1%) of which were considered contributory to the fall. A total of 351 medication changes were documented, including medication classes with known fall risk. Seventy patients (43.2%) were seen by a new specialist; 38 of 108 visits (35.2%) were trauma-related, while 70 (64.8%) addressed new non-ocular conditions. Age-stratified one-year mortality rates were: ≤65 years, 9.7%; 66-75, 15.0%; 76-85, 16.7%; >85, 45.0%.
conclusionsMost fall-related OGIs occur in the context of newly diagnosed systemic illness, worsening of chronic disease, or medication changes. These injuries may represent sentinel events signaling underlying health deterioration. Systemic evaluation at initial presentation could facilitate timely referral and management of serious non-ophthalmic conditions.
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