ArticleCommunications biology2026
A long noncoding RNA modulates anthocyanin biosynthesis in Camellia sinensis.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Tea, derived from the leaves of Camellia sinensis, is a globally consumed beverage with considerable nutritional and economic value. Specific cultivars exhibit a striking purple leaf coloration due to anthocyanin accumulation, yet the molecular mechanisms governing this trait remain incompletely understood. In this study, we identified a sense-intronic long non-coding RNA, Cs_lncRNA.18443.6, that is co-expressed with CsUFGT (UDP-glucose: flavonoid 3-O-glucosyltransferase) and is predicted to act in cis on this gene. Together with the transcription factor CsMYB12, these components form a hypothesized three-tier regulatory module that contributes to anthocyanin accumulation in purple tea leaves. CsUFGT emerges as a potential regulatory hub in anthocyanin biosynthesis. Weighted gene co-expression network analysis (WGCNA), combined with the construction of a competing endogenous RNA network construction reveals Cs_lncRNA.18443.6 as a cis-acting lncRNA associated with CsUFGT expression. This association was supported by RNA fluorescence in situ hybridization (FISH), transient expression assays in transgenic tobacco, and RT-qPCR analysis. Dual-luciferase reporter assays provided preliminary evidence that Cs_lncRNA.18443.6 influences CsUFGT transcription by affecting CsMYB12-dependent promoter activation. These findings uncover a previously uncharacterized lncRNA association with anthocyanin biosynthesis and offer new hypotheses and provide candidate targets for the molecular breeding of anthocyanin-enriched tea cultivars.
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