Evidence map›Paper›PMID 41839901›Full record

ArticleNature communications2026

Magnaporthe oryzae MoPh1 perceives ER stress and promotes adaptive responses via a plasma membrane-to-vacuole pathway.

Ziyi Yin, Jiayun Xu, Shijie Ma, Jiazong Liu, Tianfeng Zhao, Yuanchen Li, Yi Wang, Chunyan Liu, Ziming Wang, Yanke Jiang and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Ziyi Yin *State Key Laboratory of Wheat Improvement, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, China.
Jiayun Xu *Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences, Shanghai Normal University, Shanghai, China.
Shijie Ma *State Key Laboratory of Wheat Improvement, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, China.
Jiazong LiuState Key Laboratory of Wheat Improvement, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, China.
Tianfeng ZhaoState Key Laboratory of Wheat Improvement, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, China.
Yuanchen LiState Key Laboratory of Wheat Improvement, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, China.
Yi WangState Key Laboratory of Wheat Improvement, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, China.
Chunyan LiuState Key Laboratory of Wheat Improvement, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, China.
Ziming WangState Key Laboratory of Wheat Improvement, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, China.
Yanke JiangState Key Laboratory of Wheat Improvement, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, China.
Haimiao ZhangState Key Laboratory of Wheat Improvement, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, China.
Chongchong LuState Key Laboratory of Wheat Improvement, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, China.
Yingying QinState Key Laboratory of Wheat Improvement, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, China.
Ziying KongState Key Laboratory of Wheat Improvement, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, China.
Shi-En LuDepartment of Biochemistry, Molecular Biology, Entomology and Plant Pathology, Mississippi State University, Mississippi, MS, USA.
Congming LuState Key Laboratory of Wheat Improvement, College of Life Science, Shandong Agricultural University, Taian, Shandong, China.ORCID http://orcid.org/0000-0002-0337-4070
Yang LiState Key Laboratory of Wheat Improvement, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, China. yangli1988@sdau.edu.cn.
Xinhua DingState Key Laboratory of Wheat Improvement, College of Plant Protection, Shandong Agricultural University, Taian, Shandong, China. xhding@sdau.edu.cn.ORCID http://orcid.org/0000-0002-6510-5992

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During growth and development, cells experience both internal and external stresses, which can exert harmful impacts if they are poorly managed. Endoplasmic reticulum (ER) stress is an internal stress that is induced when protein misfolding or perturbations occur at excess rates, and the conventional response pathways from the ER to the nucleus are activated to address the stress. However, the involvement of the plasma membrane (PM) system in response to this internal stress has been insufficiently investigated. Here, a PM sensor, MoPh1, was observed to perceive stress through ER-PM contact sites and target the autophagosome and vacuole, consequently stimulating the autophagy process and supporting stress relief. The PM-to-vacuole pathway mediated by MoPh1 is independent of the classical ER-to-nucleus pathway and might be highly important in both fungi and plants, as it plays a crucial role in alleviating ER stress and promoting cellular adaptation for cell survival.

Indexed as

Cell MembraneEndoplasmic Reticulum StressFungal ProteinsVacuolesAdaptation, PhysiologicalAscomycotaAutophagosomesAutophagyEndoplasmic ReticulumSignal TransductionFungal Proteins

Identifiers

PMID41839901
PMCPMC13136391

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.