Evidence map›Paper›PMID 41839866›Full record

ArticleNature communications2026

Impact of NPAS2 on mPFC dopamine synthesis and nap behavior.

Lianxia Guo, Haobin Cen, Yuwei Huang, Zanjin Li, Kengran Zeng, Zicong Wu, Jiaxian Weng, Xiaocao Guo, Di He, Xinyu Liu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Lianxia Guo *Institute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.
Haobin Cen *Institute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.
Yuwei Huang *Institute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.
Zanjin LiInstitute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.
Kengran ZengDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
Zicong WuInstitute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.
Jiaxian WengInstitute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.
Xiaocao GuoDepartment of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China.
Di HeInstitute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.
Xinyu LiuInstitute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.
Zhehan YangInstitute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.
Haiman XuInstitute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.
Tingying HaoInstitute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China.
Binbin WeiSchool of Pharmacy, China Medical University, Shenyang, China. bbwei@cmu.edu.cn.ORCID http://orcid.org/0000-0001-6785-4308
Xingxing DiaoShanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China. xxdiao@simm.ac.cn.ORCID http://orcid.org/0000-0002-6892-0861
Baojian WuInstitute of Molecular Rhythm and Metabolism, Guangzhou University of Chinese Medicine, Guangzhou, China. bj.wu@hotmail.com.ORCID http://orcid.org/0000-0003-4629-5142

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82404741
6 · The paper itself

Abstract

The biological basis of the afternoon nap, a widespread yet poorly understood phenomenon, has remained elusive. Here we identify NPAS2, among core circadian regulators, as a sex-independent determinant of the nap behavior in mice. Specifically, medial prefrontal cortex (mPFC)-expressed NPAS2 orchestrates nap regulation through circadian modulation of local dopaminergic activity. We demonstrate that tyrosine hydroxylase-positive (TH

Indexed as

Basic Helix-Loop-Helix ProteinsCircadian RhythmDopamineNerve Tissue ProteinsPrefrontal CortexAnimalsBehavior, AnimalDopaminergic NeuronsMaleMiceMice, Inbred C57BLTyrosine 3-MonooxygenaseBasic Helix-Loop-Helix ProteinsDopamineNerve Tissue ProteinsNpas2 protein, mouseTyrosine 3-Monooxygenase

Identifiers

PMID41839866
PMCPMC13136427

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.