Evidence map›Paper›PMID 41839847›Full record

ArticleNature communications2026

Synchronous activation of striatal cholinergic interneurons induces local serotonin release.

Lior Matityahu, Zachary B Hobel, Noa Berkowitz, Jeffrey M Malgady, Naomi Gilin, Joshua L Plotkin, Joshua A Goldberg

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Lior MatityahuDepartment of Medical Neurobiology, Institute of Medical Research Israel - Canada, Faculty of the Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID 0000-0002-6115-8608
Zachary B HobelDepartment of Neurobiology and Behavior, Center for Nervous System Disorders, Stony Brook University Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.ORCID 0000-0002-8229-027X
Noa BerkowitzDepartment of Medical Neurobiology, Institute of Medical Research Israel - Canada, Faculty of the Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.
Jeffrey M MalgadyDepartment of Neurobiology and Behavior, Center for Nervous System Disorders, Stony Brook University Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.ORCID 0000-0002-1129-2155
Naomi GilinDepartment of Medical Neurobiology, Institute of Medical Research Israel - Canada, Faculty of the Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID 0000-0003-0638-532X
Joshua L PlotkinDepartment of Neurobiology and Behavior, Center for Nervous System Disorders, Stony Brook University Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.ORCID 0000-0001-6232-7613
Joshua A GoldbergDepartment of Medical Neurobiology, Institute of Medical Research Israel - Canada, Faculty of the Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel. joshua.goldberg2@mail.huji.ac.il.ORCID 0000-0002-5740-4087

Funding

Israel Science Foundation (ISF) 1959/22United States - Israel Binational Science Foundation (BSF) 2021212U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) NS 104089
6 · The paper itself

Abstract

Striatal cholinergic interneurons (CINs) can drive local dopamine release via nicotinic acetylcholine receptors (nAChRs) expressed on dopaminergic axons, but their role in modulating serotonin (5-HT) signaling is poorly understood. Here, we show that synchronous activation of CINs directly triggers local 5-HT release in the dorsal striatum via nAChRs expressed on serotonergic axons. This CIN-5-HT coupling is not detectable in the ventral striatum, despite its substantially denser serotonergic innervation. The nAChR-dependent release not only increases 5-HT levels in the dorsal striatum, but also expands the spatial footprint of serotonergic signaling. In Sapap3

Indexed as

Cholinergic NeuronsCorpus StriatumInterneuronsSerotoninAcetylcholineAnimalsAxonsDopamineMaleMiceMice, Inbred C57BLMice, KnockoutNerve Tissue ProteinsReceptors, NicotinicAcetylcholineDopamineNerve Tissue ProteinsReceptors, NicotinicSerotonin

Identifiers

PMID41839847
PMCPMC12992816

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.