ArticleACS applied materials & interfaces2026
Spatially Organized DNA-Templated Silver Nanoclusters as Potent Antimicrobial Agents for ESKAPE Infections.
Article in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- RNA-DNA Fusomer Fibers With Customizable Physicochemical, Mechanical, and Biological Properties for Next-Generation Therapeutics.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Dual-Action Nucleic Acid Nanoparticles: Innate Immune Activation and Silver Nanocluster-Mediated Targeting of Intracellular Bacteria.ACS nano medicine · 2026Article
- DNA-Templated Silver Nanoclusters Demonstrate Potent Antimicrobial Activity Against the Clinically Relevant Pathogens,ACS applied bio materials · 2026Article
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Authors and funding
15 authors.
Funding
Abstract
Antibiotic-resistant bacteria cause more than one million deaths annually worldwide. The rapid evolution and horizontal gene transfer among pathogens frequently render newly developed antibiotics ineffective shortly after their introduction, underscoring the urgent need for alternative therapeutic strategies. Nanoscale silver is well known for its innate antimicrobial activity but typically requires high concentrations for efficacy that causes toxicities and limits broader clinical applications. To overcome these limitations, we introduce programmable, self-assembling DNA scaffolds that template, stabilize, and spatially organize multiple copies of monodisperse silver nanoclusters (DNA-AgNCs). These nanoscale assemblies enhance the antimicrobial potency of formulations while exhibiting intrinsic fluorescence, providing a dual functionality for therapeutic and fluorescence probing applications. Comprehensive characterization revealed DNA-AgNCs with superior stability and potent activity against clinically relevant antibiotic-resistant ESKAPE pathogens. Also, DNA-AgNCs significantly reduced the intracellular bacterial burden in primary murine bone cells infected with
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Registered trials
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