ArticleAPMIS : acta pathologica, microbiologica, et immunologica Scandinavica2026
Detection of Fungal Translocation in Patients With Alcohol Use Disorder Using a Real-Time PCR Assay.
Article in APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03861325 (Insuffisance Gastro-intestinale Aiguë Translocation Microbienne Chez Les Patients en Choc Septique), which is not on this map. Not yet cited in PubMed.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Insuffisance Gastro-intestinale Aiguë Translocation Microbienne Chez Les Patients en Choc Septique : Une étude Pilote
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10 authors.
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Abstract
Gut microbiota plays a key role in triggering various diseases. However, translocation studies focus on bacteria, neglecting fungal elements, while fungi seem also involved in triggering various diseases. Aim of this study was to assess whether fungal elements were able to translocate in patients with AUD (alcohol use disorder) and to verify if withdrawal from alcohol was beneficial on such translocation. Sixty-five patients with AUD were included. Blood samples were collected at baseline and 3 and 6 weeks after alcohol withdrawal. Total DNA was extracted from blood. Fungal DNA was searched by qRT-PCR with panfungal primers and sequenced to determine the species detected. Out of 42 patients tested, 30.9% (13/42) had positive signals on one or several of their samples. Identified DNAs were mostly Candida albicans. No significant variation in mean level of fungal DNA copies was found over time in these patients. No correlation was found between intestinal integrity markers and fungal translocation. Fungal DNA was found in the blood of AUD patients, showing that fungal elements can translocate across the intestinal barrier. Absence of correlation between intestinal integrity markers and fungal translocation indicates that fungal elements may be able to translocate independently of the integrity of gut barrier.
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