Evidence map›Paper›PMID 41839681›Full record

ArticleJournal, genetic engineering & biotechnology2026

Potential role of Adansonia digitata nanoparticles on colorectal cancer induced by colorectal cancer cells (SW620) in nude mice.

Lama R Alagel, Afrah F Alkhuriji, Manal A Awad, Doaa M Elnagar, Wejdan S Al-Qahtani, Zainab M Almasawi, Yasser A Alshawakir, Nada M Merghani, Nawal M Al-Malahi

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Article in Journal, genetic engineering & biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lama R AlagelKing Saud University, College of Science, Zoology Dept. Riyadh, Saudi Arabia.
Afrah F AlkhurijiKing Saud University, College of Science, Zoology Dept. Riyadh, Saudi Arabia.
Manal A AwadKing Saud University, King Abdullah Institute for Nanotechnology, Riyadh, Saudi Arabia.
Doaa M ElnagarKing Saud University, College of Science, Zoology Dept. Riyadh, Saudi Arabia.
Wejdan S Al-QahtaniKing Saud University, College of Science, Zoology Dept. Riyadh, Saudi Arabia.
Zainab M AlmasawiKing Saud University, College of Science, Zoology Dept. Riyadh, Saudi Arabia.
Yasser A AlshawakirKing Saud University, College of Medicine, Experimental Surgery and Animal Lab, Prince Naif for Health Research Center (PNHRC), Riyadh, Saudi Arabia.
Nada M MerghaniKing Saud University, Central Research Laboratory - Vice Rectorate for Graduate Studies and Scientific Research, Riyadh, Saudi Arabia.
Nawal M Al-MalahiKing Saud University, College of Science, Zoology Dept. Riyadh, Saudi Arabia. Electronic address: nalmalahi@ksu.edu.sa.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundColorectal cancer is among the most lethal malignancies worldwide and represents the second most commonly diagnosed cancer in both males and females globally. According to the Saudi Health Council (2020), colorectal cancer ranks first among Saudi males and third among Saudi females. The present study aimed to investigate the therapeutic potential of Adansonia digitata nanoparticles against colorectal cancer induced by SW620 human colorectal cancer cells in mice.

resultsThe findings indicate that Adansonia digitata nanoparticles may represent a potential adjunctive therapeutic strategy for the treatment of colorectal cancer.

conclusionsAdansonia digitata nanoparticles (ADNPs), particularly the encapsulated formulation (ADNPs2), demonstrated promising therapeutic potential in colorectal cancer. Treatment with ADNPs improved colonic histoarchitecture and modulated key inflammatory and apoptotic signaling pathways. Although several molecular markers did not exhibit statistically significant changes, consistent pro-apoptotic trends, downregulation of transforming growth factor-β (TGF-β), and reduced tumor invasion were observed, indicating notable anticancer activity. These findings suggest that ADNPs2 may represent a potential adjunctive strategy for the management of colorectal cancer.

Indexed as

Adansonia digitataCancerExpressionNanoparticles

Identifiers

PMID41839681
PMCPMC12860714

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.